DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11835 and RAB11FIP1

DIOPT Version :9

Sequence 1:	NP_001259835.1	Gene:	CG11835 / 33232	FlyBaseID:	FBgn0031264	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001002814.2	Gene:	RAB11FIP1 / 80223	HGNCID:	30265	Length:	1283	Species:	Homo sapiens

Alignment Length:	1170	Identity:	221/1170 - (18%)
Similarity:	366/1170 - (31%)	Gaps:	437/1170 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKRLQAQVRIGGKGTPRRKKKVMHQTAATDDKKLQSSLKKLSVSTIPG--------IE-EVNIIK 61
            |.|.:..:|...:...|||         |...||:|.         ||        || ::..::
Human   104 LGRAEVDLRDLHRDQGRRK---------TQWYKLKSK---------PGKKDKERGEIEVDIQFMR 150

  Fly    62 DDLTVIHFNNPKAQASLSANTFAVTGHGETRKVVE-------------MLPDILPQL--GQETVV 111
            :::|...|:  .:....|.|.|     |:.:..::             ::|...|.:  ..|:||
Human   151 NNMTASMFD--LSMKDKSRNPF-----GKLKDKIKGKNKDSGSDTASAIIPSTTPSVDSDDESVV 208

  Fly   112 -------QLRMYANAMNSQKGAPGSGDGPLPAEEDDDVPLLVGDF------DEVAKVEATKQPVH 163
                   :::...:..|.||.........||..:.:.|.|..|||      |:.....::...|.
Human   209 KDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSASDVM 273

  Fly   164 EPKESAEIKAKDKQQQQ---PKK------------------------------EQKQSAKVPETT 195
            ..|.:|....|...|..   |||                              ||.::....:.:
Human   274 SHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDS 338

  Fly   196 NPSENPKEKQENKK-----------GQAKNNKKG-----DPQTNKDKTNKSKDQAKG------QP 238
            :||.:|..|...||           |..|...:|     |.|.::..|   ||..|.      :|
Human   339 SPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESST---KDSLKSMTLPSYRP 400

  Fly   239 AP-----------QANKETTQAAQALK-------------------------QNPSKPAVQQKKD 267
            ||           .||.|.|:.|:..|                         :||.....::|:.
Human   401 APLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEG 465

  Fly   268 QVLAVDQKIEANG----AIQKAQQPKPA-------------ETKSTDQKVEPKSAEKQVDKAKPI 315
            .::.|....:|:|    .::::::...|             :.:.|:.:.||   |.:.:...||
Human   466 MLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEP---ESKSEPRPPI 527

  Fly   316 EQTKTKESKVEHPKPAQKQLDQNTQAKPTAERSEAKPVVPTPEPQKSAPPAVQTLAQIVALP--- 377
            ...:..:::...|:     |:.:.:|:|||.       :|:|....|:.|.:.:.:...::|
Human   528 SSPRAPQTRAVKPR-----LEVSPEAQPTAR-------LPSPTDSPSSLPPLPSSSGQASVPSEL 580

  Fly   378 --------AEKPA-----NEAVAAPKAEEQKKDS-----SGPAKVE-PAITPSA--------PQP 415
                    :|.|:     :..:|||.:.....:|     .|.||.| |.:.|.|        |.|
Human   581 GHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPLLPKAELQTESLTPVP 645

  Fly   416 VTTAEPPKSALKQDSPPKSAPKQGS---------PPKNVPKQESPPQSAPKQDSPPKGAPKQDSP 471
            .:.:....|..||.|.|.:...:.|         ..||....|. .:|.|:|  |..|..:::.|
Human   646 NSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLEL-EESLPEQ--PETGRQEEELP 707

  Fly   472 PKGAPKQDSPPKGAPKQD-----SAPQQKTPPPVKQEVAPAKQD-------------EPPAKQDA 518
            .....|||..|.....|:     |........||.:..|...:|             ...|::.|
Human   708 RFPCKKQDYSPSSGEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVA 772

  Fly   519 PPAKQDAPVP-VPEVIKTLAPEVPNVSQAPAQPQGQAALA-----SEKPADAPKAIEEPKAAPKK 577
            ||....|.|| :..:::.|.....|:.:...:.:.:.:.:     .|..|.|...:|...:.|::
Human   773 PPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVSFSEQLFTEEAVAGAALLVEGHSSCPQE 837

  Fly   578 ESP------------PPTKP---------VTATVPV---APATPAEAPSPLAPSTPPSTPTSVPP 618
            .:|            ||..|         ||...|.   |||:||:  ..|.||...|. :.||.
Human   838 LNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPAD--HLLLPSQEESF-SEVPM 899

  Fly   619 SAATVTPPSP--------ATVT--------------------------------------PPSPA 637
            |.|:....:|        |.||                                      |..|.
Human   900 SEASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPE 964

  Fly   638 VVTPPQKQSAAPQAGIKKQEAGTKTKQ--------------------QQPANKP----------- 671
            |.:..::.......|.:.::.|...|.                    :.|:.:.
Human   965 VASDDERIDQVEDDGDQVEDDGETAKSSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCD 1029

  Fly   672 ---QQPQ---------------------------KQPPGGAGG-SAGPGGNKGVQKQPNPNA-KP 704
               |.||                           ||.||.:|| ...|.||......|..:. .|
Human  1030 FRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGNGSPSPPPGTSLDNP 1094

  Fly   705 AVAPKPAQATP----------------------KPAAASPKA-----------------SPNQTN 730
            ..:|.|::..|                      |.|.|...|                 ||::|:
Human  1095 VPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETH 1159

  Fly   731 PQQQQ-----GKAANKASPPKQTGPTGGQQKSAANASKATASPKSAASPKATSPKAGTPTNPASA 790
            |...|     |.|.::..|.|   |........||.|..||:..|.........|..:|::||.|
Human  1160 PVSAQPGAGTGSAKHRLHPVK---PMNAMATKVANCSLGTATIISENLNNEVMMKKYSPSDPAFA 1221

Fly 791 790
Human 1222 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11835	NP_001259835.1	NAC	38..91	CDD:280093	13/61 (21%)
RAB11FIP1	NP_001002814.2	C2_Rab11-FIP_classI	20..147	CDD:176064	14/60 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..281		23/124 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..727		83/417 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..782		8/40 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..913		22/80 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	969..993		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1037..1141		18/103 (17%)
		Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recycling	1219..1283		2/3 (67%)
		RBD-FIP	1226..1273	CDD:255374
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000