DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11835 and Rab11fip1

DIOPT Version :9

Sequence 1:	NP_001259835.1	Gene:	CG11835 / 33232	FlyBaseID:	FBgn0031264	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_036010246.1	Gene:	Rab11fip1 / 75767	MGIID:	1923017	Length:	1170	Species:	Mus musculus

Alignment Length:	1058	Identity:	205/1058 - (19%)
Similarity:	344/1058 - (32%)	Gaps:	360/1058 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKRLQAQVRIGGKGTPRRKKKVMHQTAATDDKKLQSSLKKLSVSTIPGIEEVNIIKDDLTVIHFN 70
            |.|.:..:|...:...||||:  ..|..:...|......::.|       ::..:::::|...|:
Mouse   106 LGRAEVDLRELHRDQGRRKKQ--WYTLKSKPGKKDKERGEIEV-------DIQFMRNNMTASMFD 161

  Fly    71 --------NP------------KAQASLSANTFAVTGHGETRKVVEMLPDILPQL---------G 106
                    ||            |..||.:|:.              ::|.:.|.:         .
Mouse   162 LSMKDKSRNPFGKLKDKIKGKNKDSASDTASA--------------IVPSVTPSVDSDDESFSKD 212

  Fly   107 QETVVQLRMYANAMNSQKGAPGSGDGPLPAEEDDDVPLLVGDFDEVAKVEATKQPVHEPKESA-- 169
            ::...:::...:..:.||.........||..:.|.|.|..|||......:|     ||.:.|:
Mouse   213 KKKKSKIKTLFSKSSLQKTPLSQSMSVLPTSKSDKVLLRAGDFQSQWDDDA-----HEDESSSAS 272

  Fly   170 ------EIKAKDKQQQQ-----PKK------------------------------EQKQSAKVPE 193
                  ...:.|:|..|     |||                              ||.::.....
Mouse   273 DVMSHKRTSSTDQQPNQSNFSLPKKEGLSFLGGLRSKNDSLSRSTVCINGNHVYMEQPEARSEIR 337

  Fly   194 TTNPSENPKEKQENKK---GQAKNNKKGDPQ-------TNKDK---TNKSKDQAKGQPAPQ---- 241
            .::||.:|..:...:|   ...:|.....|:       |:.|:   .:.:||..|....|.
Mouse   338 ESSPSNSPSPQGFRRKHLFSSTENLAARSPKEPGEGGGTSSDRRLSDSSTKDSMKSMSLPSYRPL 402

  Fly   242 ---ANKETTQAA--QALKQNPSKPAVQQKKDQVLA-VDQKIEANGAIQKAQQPKPAETKSTDQK- 299
               .|:|:...|  :|.::.......:.||..:|: |..|   ..|..|..:.:|..|.|..:|
Mouse   403 TSGDNRESMSPANVEAARETKDSKKQESKKSSLLSLVTGK---RDAAAKGSESEPLPTVSEKEKE 464

  Fly   300 -----VEPKSAEKQV----------------DKAKPIEQTK------TKESKVEHPKP--AQKQL 335
                 ||.:..|:.:                ....|.|..:      |.||:.| |||  ...::
Mouse   465 RKGALVEAQLREEDLMRRPEKDALPVASQWGSSLNPFEDVQISDPGATTESRSE-PKPPVPAARV 528

  Fly   336 DQNTQAKPTAERS-EAKPVVPTPEPQKS----------APPAVQTL-----AQIVALPAEKPANE 384
            .|....||..|.| ||:|....|.|..:          .||.:..|     .|....|:......
Mouse   529 PQTKAVKPRLEVSPEAQPKARLPSPDSALFAPFPSDSIQPPVLSDLRCDSETQFSESPSASSFLS 593

  Fly   385 AVAAP----------KAEEQKKDSSGPA---KVEPAITPSA--------------PQPVT--TAE 420
            .:|||          ...:.:.|:..|:   :..|::||:|              |.||.  |.|
Mouse   594 PLAAPISTSTPVEPWPTGQGEADAEKPSLLLRAVPSLTPAANTGSSASGSPCEQLPTPVRKGTEE 658

  Fly   421 PPKSALKQ----------------------DSPPKSAPKQGSPPKNVPKQESPPQSAPKQDSPPK 463
            ......|:                      |....:|.::.:||....:..|..:.|.|.:...:
Mouse   659 ASGDTRKEAGSDESGKTLMTECVSSVDNVHDGGMTTAGEEAAPPLLEDEASSFHRIAQKHEGMHQ 723

  Fly   464 GAPKQDSPPKGAPKQDSPPKGAPKQDSAPQ----QKTPPPVKQEVAPAKQDEPPAKQDAPPAKQD 524
            .|       .|..|     ||..:...:.|    ::|..|.:.|    ::|...|:|    ..|:
Mouse   724 NA-------SGGQK-----KGKKRVSFSEQLFVEEETEGPTRLE----EEDRGHAQQ----LTQE 768

  Fly   525 APVPVPEVIKTLAPEVPNVSQAPAQPQGQAALASEKPADAPKAIEEPKAAPKKESPPPTKPVTAT 589
            .|| ...|::..:||.|:     .:..||..:.:|.   .|....|.|..|:.
Mouse   769 GPV-AGSVLRAGSPESPH-----TEGTGQEPVTAEA---QPNISSEGKCFPEG------------ 812

  Fly   590 VPVAPATPAEAPSPL--------APSTPP--------STPTSVPPSAATVTPPSPATVT---PPS 635
             |.:.|:||....||        ||....        |.|.|..|||:.|..|..|.::   |..
Mouse   813 -PTSEASPARGTQPLMDEKDDLMAPCQSKASDHEGLLSNPLSDLPSASDVKSPIIADLSLSLPSI 876

  Fly   636 PAVVTPPQKQSAAPQAGIKKQ----EAGTK------------------------TKQQ---QPAN 669
            |.|.:..::.......|..::    |||..                        |:.|   :|..
Mouse   877 PEVASDDERVDEVGDGGKAEKLVDLEAGVSPWNVSHSILETSGRSSGRAGESVPTENQCDFRPQV 941

  Fly   670 KPQQPQKQPPGGAGGSAGPGGNK-----GVQKQPNP--NAKPAVAPKPAQATPKPAA-ASPKASP 726
            :..:.::.|        |||..:     |.:|..:|  .::.:..|.|:.|...||| :||.:.|
Mouse   942 RSSENEELP--------GPGTVEEEKLIGGEKPASPLCVSQDSSVPSPSVAETFPAAYSSPSSPP 998

  Fly   727 NQTN-----PQQQQ-------GKAAN--KASP-------PKQTGPTGGQQKSAANASK---ATAS 767
            :.|:     ..|:|       .:|.|  |..|       |.:..||.....:.|.|:|   ....
Mouse   999 SDTHHTSEAESQKQATADVSTSRAENFGKKKPLLQAWVTPSEIHPTPALPSAGAGAAKHRPHPVK 1063

  Fly   768 PKSAASPKATSPKAGTPT 785
            |.:..:.|..:...||.|
Mouse  1064 PMNTTATKIANSSLGTAT 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11835	NP_001259835.1	NAC	38..91	CDD:280093	10/72 (14%)
Rab11fip1	XP_036010246.1	C2_Rab11-FIP_classI	20..149	CDD:176064	10/51 (20%)
Rab11fip1	XP_036010246.1	PHA03247	<489..651	CDD:223021	34/162 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000