DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11835 and CX3CL1

DIOPT Version :9

Sequence 1:	NP_001259835.1	Gene:	CG11835 / 33232	FlyBaseID:	FBgn0031264	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_002987.1	Gene:	CX3CL1 / 6376	HGNCID:	10647	Length:	397	Species:	Homo sapiens

Alignment Length:	336	Identity:	77/336 - (22%)
Similarity:	115/336 - (34%)	Gaps:	99/336 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 PKPAETKSTDQKVEPKSA---------EKQVDKAKPIEQTKTKESKVEHPKPAQKQLDQNTQAKP 343
            ||....|...|.::.::|         |||:.:.||            ...||...:|::...:|
Human    77 PKEQWVKDAMQHLDRQAAALTRNGGTFEKQIGEVKP------------RTTPAAGGMDESVVLEP 129

  Fly   344 TAERSEAKPVVPTPEPQKSAPPAVQTLAQIVALPAEKPANEAVAAPKAEEQKKDSSGPAKVEPAI 408
            .| ..|:..:.|||..|:    |.:.|.....||.....:.....|..  .|....||...|...
Human   130 EA-TGESSSLEPTPSSQE----AQRALGTSPELPTGVTGSSGTRLPPT--PKAQDGGPVGTELFR 187

  Fly   409 TPSAPQPVTTAEPPKSALKQDSPPKSAPKQGSPPKNVPKQESPPQSAPKQDSPPKGAPKQDSPPK 473
            .|    ||:||...:|         |||.|..|..   ..|:....||....|...|....||
Human   188 VP----PVSTAATWQS---------SAPHQPGPSL---WAEAKTSEAPSTQDPSTQASTASSP-- 234

  Fly   474 GAPKQDSPPKG--------APKQDSAPQQKTPPPVKQEVAPAKQDEPPAKQDAPPAKQDAPVPVP 530
             ||::::|.:|        :|:.:::.:::...||     ||..|   |.||..|.
Human   235 -APEENAPSEGQRVWGQGQSPRPENSLEREEMGPV-----PAHTD---AFQDWGPG--------- 281

  Fly   531 EVIKTLAPEVPNVSQAPAQPQGQAALASEKPADAPKAIEEPKAA----PKKESP--PPTKPVTAT 589
                    .:.:||..|...:|..:             .||.|:    ||.|.|  ....|....
Human   282 --------SMAHVSVVPVSSEGTPS-------------REPVASGSWTPKAEEPIHATMDPQRLG 325

  Fly   590 VPVAPATPAEA 600
            |.:.|...|:|
Human   326 VLITPVPDAQA 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11835	NP_001259835.1	NAC	38..91	CDD:280093
CX3CL1	NP_002987.1	Chemokine_CX3C	25..100	CDD:238172	5/22 (23%)
		Chemokine and involved in interaction with ITGAV:ITGB3 and ITGA4:ITGB1. /evidence=ECO:0000269\|PubMed:23125415	25..100		5/22 (23%)
		Mucin-like stalk	101..341		72/312 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..265		39/162 (24%)
		dnaA	131..>324	CDD:333091	59/256 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..309		5/32 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000