Protein Alignment uncNacbeta and OTOG

DIOPT Version :10

• Sequence 1: NP_608532.1
• Gene: uncNacbeta / 33232
• FlyBaseID: FBgn0031264
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001264198.1
• Gene: OTOG / 340990
• HGNCID: 8516
• Length: 2925
• Species: Homo sapiens
• Alignment Length: 642
• Identity: 146/642 - (22%)
• Similarity: 220/642 - (34%)
• Gaps: 153/642 - (23%)

  Fly   228 NKSKDQAKGQPAPQANKETTQAAQALKQNPS-KPAVQQKKDQVLAVDQKIEANGAIQKAQQP--K 289
            |::...::|.|.|  :.|..|.:|...:.|: :||:........|::..:.|      .::|  .
Human  1478 NETLPPSQGLPTP--SDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTA------TEEPVVS 1534

  Fly   290 PAETKSTDQKVEPKSAEKQVDKAKPIEQTKTKESKVEHPKPAQKQLDQNTQAKPTAERSEAKPV- 353
            |..|::|.|              :|:|.|.::........||.|.:..:..|.|....|.:.||
Human  1535 PGPTQTTLQ--------------QPLELTASQLPAGPTESPASKGVTASLLAIPHTPESSSLPVA 1585

  Fly   354 VPTPEP------------------------QKSAPPA----VQTLAQIV----ALPAE------- 379
            :.||.|                        ...:|||    :.|.|..|    :||..
Human  1586 LQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPS 1650

  Fly   380 ---KPANEAVAAPKAEEQKKDSSGPAKVEPAITPSAPQPVT-TAEP-PKSALKQDSPPKSAPKQG 439
               .|::..||:|.|..:...|||..|.  .:||:..:.:: |..| |..|....||.......|
Human  1651 LTASPSSRPVASPGAISRSPTSSGSHKA--VLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAG 1713

  Fly   440 SPPKNVPKQESPPQSAPKQDSPPKGAPKQDSPPKGAPKQDSP---PKGAPKQDSAPQQKTPPPVK 501
            :..:.||......:|.....|..||.... |.|.|:|....|   |...|:    |.|.|....:
Human  1714 TAAEQVPVSPLATRSLEIVLSTEKGEAGH-SQPMGSPASPQPHPLPSAPPR----PAQHTTMATR 1773

  Fly   502 QEVAPAKQDEPPAKQDAPPAKQDAPVPVPEVIKTLAPEVPNVSQAPAQPQGQAALASEKPAD--- 563
               :||...|.||......|....         ...|.:...|..|:|      |.|..|.|
Human  1774 ---SPALPPETPAAASLSTATDGL---------AATPFMSLESTRPSQ------LLSGLPPDTSL 1820

  Fly   564 --APKAIEEPKAAPKKESPPPTKPVTATVPVAPATPAEAPSPLAPSTPPS-----TPTSVPPSAA 621
              |......|.|.|..::...|.|:.   |.|...||:..||:.|.||.:     .||.:.|.||
Human  1821 PLAKVGTSAPVATPGPKASVITTPLQ---PQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAA 1882

  Fly   622 TVTPPSPATVTPPSPAVVTPPQKQSAAPQAGIKKQEAGTKTKQQQPANKPQQPQKQP--PGGAGG 684
            ...|......|.|:..|:  |..:..|....:..:::.|        .|.....||.  |....|
Human  1883 GTAPGLLLGATLPTSGVL--PVAEGTASMVSVVPRKSTT--------GKVAILSKQVSLPTSMYG 1937

  Fly   685 SAGPGGNKGVQKQPNPNAKPAVAPKPAQ---ATPKPAAASPKASPNQTNPQQ-------QQGKAA 739
            ||..|..:......:|.......|:.||   |.|.|.:.:......:|.||.       |..:|
Human  1938 SAEGGPTELTPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSARTAPQDSMLVLLPQLAEA- 2001

  Fly   740 NKASPPKQTGPTGGQQKSAANASKATASPKSAASPK-----------ATSPKAGTPT 785
                    .|.:.|...:|....:||..|...::|.           ||:.:|.|.|
Human  2002 --------HGTSAGPHLAAEPVDEATTEPSGRSAPALSIVEGLAEALATTTEANTST 2050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
uncNacbeta	NP_608532.1	NAC_BTF3	4..120	CDD:409234
		PTZ00121	<190..>407	CDD:173412	48/224 (21%)
		PHA03247	<355..794	CDD:223021	118/511 (23%)
OTOG	NP_001264198.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..69
		VWD	152..302	CDD:459671
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..335
		C8	349..412	CDD:462584
		TIL	426..474	CDD:460351
		VWC_out	476..>511	CDD:214565
		VWD	514..669	CDD:459671
		C8	713..767	CDD:462584
		TIL	780..844	CDD:410995
		TIL	884..946	CDD:410995
		VWD	977..1131	CDD:214566
		C8	1166..1240	CDD:214843
		beta-trefoil_ABD_OTOG	1245..1396	CDD:467810
		PHA03247	<1476..2041	CDD:223021	141/631 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1476..1540		15/69 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1636..1679		11/44 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1693..1715		6/21 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1737..1788		17/58 (29%)
		VWD	2112..2266	CDD:459671
		C8	2304..2370	CDD:214843
		TIL	2373..2434	CDD:460351
		Rossmann-fold NAD(P)(+)-binding proteins	<2676..2736	CDD:473865
		CT	2842..2924	CDD:214482