DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11835 and dao-5

DIOPT Version :9

Sequence 1:	NP_001259835.1	Gene:	CG11835 / 33232	FlyBaseID:	FBgn0031264	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001021004.1	Gene:	dao-5 / 266845	WormBaseID:	WBGene00000931	Length:	971	Species:	Caenorhabditis elegans

Alignment Length:	868	Identity:	208/868 - (23%)
Similarity:	318/868 - (36%)	Gaps:	197/868 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KKLQSSLKKLSVSTIPGIEEVNIIKDDLTVIHFNNPKAQASLSANTFAV-------------TGH 88
            |||.:.||.         .|...:||.:|...|...|..||.|.|...|             :..
Worm    33 KKLDAFLKD---------NEAPKLKDIVTDNVFKKRKRIASSSGNEPPVKKMAAKDSSDSDSSDD 88

  Fly    89 GETRKVVEMLPDILPQLGQETVVQLRMYANAMNSQKGAPGSGDGPLPAEEDDDVPLLVGDFDEVA 153
            |..:|           .|.:..|.:....:|...||.|..|      :..|.|.|        ..
Worm    89 GAVKK-----------NGVQKPVNVAAKKSATPVQKKAESS------SSSDSDAP--------AK 128

  Fly   154 KVEATKQPVHEP--KESAEIKAKDKQQQQPKKEQKQSAKV-------PETTNPSENPKEKQENKK 209
            |:...|:|...|  |::|.....|...:.|||....:.||       .:.|:.|::..|..::.|
Worm   129 KLTPVKKPAQTPAQKKAASSSDSDSDDEPPKKAPAVTTKVAPKPMAKKQDTSDSDSDSEDSDDGK 193

  Fly   210 GQAKNNKKGDPQTN-------KDKTNKSKDQAKGQPAPQANKETTQAAQALKQNPSKPAVQQKKD 267
            .:..|..|..|..|       |...:.|.|.:..:..|           |.|..|:||..:
Worm   194 SKKANPVKVTPVANVLQKVVAKKAASSSSDSSDDEKKP-----------AAKPTPAKPTPK---- 243

  Fly   268 QVLAVDQKIEANGAI---QKAQQPKPAETKSTDQKVEPKSAEKQVDKAK-------PIEQTKTKE 322
               .|.:|.|::...   :|....|||..|:|     ||.|.|:.|.:.       |.::|..|.
Worm   244 ---PVVKKAESSSDSSDDEKKPVAKPAPAKAT-----PKPAAKKADSSSDSSDDEAPAKKTPAKA 300

  Fly   323 SKVEHPKPAQKQLDQNTQAKPTAERSEAKPVVPTPEPQKSAPPAVQTLAQIVA-------LPAEK 380
            :    |||..|:.:.::.:....::..|||.     |.|:.|..|...|:..:       .|..|
Worm   301 A----PKPVAKKAESSSDSSDDEKKPAAKPT-----PAKATPKPVAKKAESSSDSSDDEKKPVAK 356

  Fly   381 PANEAVAAPKAEEQKKDSSGPA---KVEPAITP----SAPQPVT-TAEPPKSALKQDSPPKSAPK 437
            || .|.|.||...:|.:||..:   :.:||..|    :.|:||. .||....:...:..|.:.|.
Worm   357 PA-PAKATPKPVAKKAESSSDSSDDEKKPAAKPTPAKATPKPVAKKAESSSDSSDDEKKPVAKPT 420

  Fly   438 QG-SPPKNVPKQ-----ESPPQSAPKQDSPPKGAPKQDSPPKGAPKQDSPPKGAPKQDSAPQQKT 496
            .. :.||...|:     :|....||.:.:|.|.|||..| .|.....||.....|...|.|.:.|
Worm   421 SAKATPKPAAKKADSSSDSSDDEAPAKKTPAKAAPKPAS-KKAESSSDSSDDEKPAAKSTPAKIT 484

  Fly   497 PPPVKQEVAPAKQD------EPPAKQDAPPAKQDAPVPVPEVIKTLAPEVPNVSQAPAQPQGQAA 555
            |.|..::||.:..|      :|.||   |......|.||.:..::.:....:..:..|:|  .:|
Worm   485 PKPTAKKVASSSSDSSDDEKKPAAK---PTPANATPKPVAKKAESSSDSSDDEKKPVAKP--TSA 544

  Fly   556 LASEKPA-------------DAPKAIEEPKAAPKKESPPPTKPVTAT-------VPVAPATPAE- 599
            .|:.|||             :||......|||||    |.:|...::       .|.|.:|||:
Worm   545 KATPKPAAKKADLSSDFSDDEAPAKKTPAKAAPK----PASKKAESSSDSSDDEKPAAKSTPAKT 605

  Fly   600 APSPLAPSTPPSTPTSVPPSAATVTPPSPATVTPPSPAVVTPPQKQSAAPQAGIKK--------- 655
            .|.|.|.....|:..|.......|..|:.|..||...|........|:..:|..||
Worm   606 TPKPTAKKAASSSSDSSDDEKKPVAKPTSAKATPKPAAKKADSSSDSSDDEAPAKKTPVKPTPVK 670

  Fly   656 ---QEAGTKTKQQQPANKPQQ--PQKQPPGGA--GGSAGPGGNKGVQKQPNPNAKPAVAPKPAQA 713
               ::..:.:.......||.:  |.|..|...  ..:|....:...:|:|.....|.|.||..:|
Worm   671 IVAKKVDSSSDSSDDEKKPTKATPVKVTPKSVTKKAAASSSDSSDDEKKPVVKQTPNVVPKKEKA 735

  Fly   714 T----------PKPAA-ASPKASPNQ------TNPQQQQGKAANKASPPKQTGPTGGQQKSAANA 761
            .          .||.| .:|||:|.|      ::......:|..|.:|.|.|......:|.|:::
Worm   736 ASSSDDSSDDEKKPTAKPTPKATPKQSAKKADSSDDSSDDEAPAKKTPAKSTPAKTAVKKEASSS 800

  Fly   762 SKATASPKSAASPKATSPKAGTP 784
            |..::..:......||:|...||
Worm   801 SDDSSDDEKTKKKSATTPAKSTP 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11835	NP_001259835.1	NAC	38..91	CDD:280093	16/65 (25%)
dao-5	NP_001021004.1	tRNA-synt_1g	<196..321	CDD:330949	34/151 (23%)
		DNA_pol3_gamma3	<262..457	CDD:331207	56/209 (27%)
		DNA_pol3_gamma3	<389..606	CDD:331207	59/226 (26%)
		Atrophin-1	<445..886	CDD:331285	96/389 (25%)
		SRP40_C	897..>945	CDD:309939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.759104	Normalized mean entropy	S2165
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.950