DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11835 and RAB11FIP5

DIOPT Version :9

Sequence 1:	NP_001259835.1	Gene:	CG11835 / 33232	FlyBaseID:	FBgn0031264	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001358201.1	Gene:	RAB11FIP5 / 26056	HGNCID:	24845	Length:	1324	Species:	Homo sapiens

Alignment Length:	870	Identity:	195/870 - (22%)
Similarity:	285/870 - (32%)	Gaps:	240/870 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DDLTVIHFNNPKAQASLSANTFAVTGHGETRKVVEMLPDILPQLGQETVVQLRMYANAMNSQKGA 126
            |..|||.....|...|:...|     ||            .|:..:|...:|            .
Human    43 DAYTVIQVGREKYSTSVVEKT-----HG------------CPEWREECSFEL------------P 78

  Fly   127 PGSGDGPLPAEEDDDVPL--------------------LVG----------DFDEV---AKVEAT 158
            ||:.||.|.|:|.|..|.                    |:|          ..|||   .:.:.|
Human    79 PGALDGLLRAQEADAGPAPWAASSAAACELVLTTMHRSLIGVDKFLGQATVALDEVFGAGRAQHT 143

  Fly   159 K------QPVHEPKESAEIKA------------------KDK----------QQQQPKKEQKQSA 189
            :      :|..:.||..||:.                  |||          :.:..||...:||
Human   144 QWYKLHSKPGKKEKERGEIEVTIQFTRNNLSASMFDLSMKDKPRSPFSKIRDKMKGKKKYDLESA 208

  Fly   190 KVPETTNPSENPKEKQENKKGQAK----NNKKGDPQTNKDKTNKSKD----QAKGQPAPQANKET 246
            .....::..|:|......|.|:||    .||.......:..|:...|    .|.|..|.|.
Human   209 SAILPSSAIEDPDLGSLGKMGKAKGFFLRNKLRKSSLTQSNTSLGSDSTLSSASGSLAYQG---- 269

  Fly   247 TQAAQALKQNPSKPAVQQKKDQVLAVDQKIEANGAIQKAQQPKPAETKST------DQKVEPKSA 305
             ..|:.|.::||:             ...:...|....||.||....|.|      ..:|.|..|
Human   270 -PGAELLTRSPSR-------------SSWLSTEGGRDSAQSPKLFTHKRTYSDEANQMRVAPPRA 320

  Fly   306 ----EKQVDKAKPIE--------QTKTKESKVEHPKPAQKQLDQNTQAKPTAER-SEAKP----- 352
                :..:|.|....        ..:..:..|.|.......|..:...:..:.| ||..|
Human   321 LLDLQGHLDAASRSSLCVNGSHIYNEEPQGPVRHRSSISGSLPSSGSLQAVSSRFSEEGPRSTDD 385

  Fly   353 VVPTPEPQKSAPPAVQTLAQIVALPAEKPANEAVAAPKAEEQKKDSSGPAKVEPAITPSAPQPVT 417
            ..|......|:..||  |.|     .|..|...|.||.|       |.|.:.|.|..|.. :||.
Human   386 TWPRGSRSNSSSEAV--LGQ-----EELSAQAKVLAPGA-------SHPGEEEGARLPEG-KPVQ 435

  Fly   418 TAEPPKSALKQDSPPKSAPKQGSPPK---------NVPKQESPPQSAPKQDSPPKGAPKQDSPPK 473
            .|.|..::.:..:..:.|.|:...|:         .:.:.|...:|:..:    ||.|...:.|.
Human   436 VATPIVASSEAVAEKEGARKEERKPRMGLFHHHHQGLSRSELGRRSSLGE----KGGPILGASPH 496

  Fly   474 GAPKQDSPPKGA---PKQDSAPQQKTPPPVKQEVAPAKQDEPPAKQDAPPAKQDAPVPVPEVIKT 535
            .:...:...|.:   .::...|.||  |.:  :|:|..:.:|.|.....|....||
Human   497 HSSSGEEKAKSSWFGLREAKDPTQK--PSL--DVSPQVESDPAALPHHLPCSPWAP--------- 548

  Fly   536 LAPEVPNVSQAPAQPQGQAALASEKPADAPKAIEEPKAAPKKESPPP-----TKPVTATVPVAP- 594
             ||..|..:.||.......|.||  ||.|..|.....|||  |:.||     |.|...::...|
Human   549 -APPTPAPTAAPMLSTNLFAAAS--PAAATAAAAATTAAP--EATPPGLLGLTNPFLTSLQSNPF 608

  Fly   595 --------ATPAEAPSPLAPSTPPSTPTSVPPSAATVTPPSPATVTPPSPAVVTPPQKQSAAPQA 651
                    |..:.:|:|..||...::||.: .|.....|....|....:.:.:.|..:......|
Human   609 FEELIADIALNSPSPAPSLPSASRASPTPL-ASPGKALPEWDNTFNVFAASRLRPEARSEILAPA 672

  Fly   652 GIKKQEAGTKTKQQQP-----ANKPQQPQKQPPGGAGGSAGPGGNKG--VQKQP------NPNAK 703
            |:..:.||.    |.|     ..|..:||.:|.||.||..|.||..|  |..:|      .||.:
Human   673 GVGLEAAGL----QDPGPGAMTAKAAEPQGEPGGGGGGGGGGGGRGGSSVWLEPRVPLDLGPNHQ 733

  Fly   704 PAVAPKPAQATPKPAAASPKASPNQTNPQQQQGKAANKASPPKQTGPTGGQQKSAANASKATASP 768
            .|.|..|. ......|..|.:|      .|.|.:|:  .|.|.:..|.   .:..|..|.|.:..
Human   734 SASAADPG-LLGSVGAGLPSSS------AQLQLRAS--GSEPDRELPA---PEVEAGQSPADSGT 786

  Fly   769 KSAASPKATSPKAGTPTNPASASGG 793
            ...:||:..|.....| .|.||:.|
Human   787 SLFSSPEVISVWERLP-GPESAAEG 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11835	NP_001259835.1	NAC	38..91	CDD:280093	9/28 (32%)
RAB11FIP5	NP_001358201.1	C2	21..167	CDD:387358	32/152 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..300		9/48 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..402		11/61 (18%)
		PHA03247	<1121..1251	CDD:223021
		RBD-FIP	1272..1319	CDD:370506
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000