DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11835 and ABI3BP

DIOPT Version :9

Sequence 1:	NP_001259835.1	Gene:	CG11835 / 33232	FlyBaseID:	FBgn0031264	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001362476.1	Gene:	ABI3BP / 25890	HGNCID:	17265	Length:	1786	Species:	Homo sapiens

Alignment Length:	1102	Identity:	225/1102 - (20%)
Similarity:	339/1102 - (30%)	Gaps:	385/1102 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DDKKLQSSLKKLSVSTIPGIEEVNIIKDDLT-----VIHFNNPKAQASLSANTFAVTGHGETRKV 94
            |.|.||.......|.:.|...:...|.|..|     ::....||...:|. ...|.....||..|
Human   420 DSKVLQPQTATYDVFSSPTTSDEPEISDSYTATSDRILDSIPPKTSRTLE-QPRATLAPSETPFV 483

  Fly    95 VEML-----PDILP--QLGQETVVQLRMYANAMNSQKGAPGSGDGPLPAEEDDDVPLLVGDFDEV 152
            .:.|     |::.|  ...|:|           .|....|.....|.|.....:.....|..  .
Human   484 PQKLEIFTSPEMQPTTPAPQQT-----------TSIPSTPKRRPRPKPPRTKPERTTSAGTI--T 535

  Fly   153 AKVEATKQP---VHEPKESAEIKAKDKQQQQPKKEQKQSAKVPETTNPS------ENPKEKQENK 208
            .|:..:.:|   ...|.::..|..|.|....|:....:.|..|:|..||      |.|..|....
Human   536 PKISKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHTKPAPEPQTLLPSQSTIGPETPGTKPSTT 600

  Fly   209 KGQAKNNKKG-DPQTN-KDKTNKSKDQAKGQPA------------------PQANKETTQAAQAL 253
            ....|..:.| .|:.. :.||..|.:..|.:||                  |....:||....|.
Human   601 LAPRKTKRPGRRPRPRPRPKTTPSPEVPKSKPALEPATIQPEPLVPTTASKPSERPKTTHRPDAP 665

  Fly   254 KQNP-SKPAVQ-QKKDQVLAVDQKIEANGAIQKAQQPKPAETKSTDQKVEPKS--------AEKQ 308
            :..| |||..| ..|.|..|....    ...:...:|.|.||::....:.|.:        .|..
Human   666 QIQPGSKPPKQLLPKPQTTAEPDM----PPTKSVSEPVPFETEAPSMTIVPTTDIEPVTVRTEAT 726

  Fly   309 VDKAKP--IEQTKTKESKVEH-----PKPAQKQLD-----QNTQAKPT-----AERSEAKP-VVP 355
            |....|  .::|:|:..:.:|     |:..|.:||     ..|.:.||     ..|...|| ..|
Human   727 VTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKPKTTP 791

  Fly   356 TPE-PQKSAPPAVQTLAQIVALPAEKPANEAVAAPKAEE-------QKKDSSGPAKVEPAITPS- 411
            .|| ||....||  |:.:.| |..|  |:...||||..:       :.|.:..|.:::..:.|:
Human   792 HPEVPQTKLVPA--TILEPV-LRTE--ASGTTAAPKVPQRTHRPHPKPKTTLSPEELQTELVPAT 851

  Fly   412 ----------AP----QPVTTAEP-------PKSAL-----KQDSPPKSAPKQGSPP-------- 442
                      ||    .|||..||       |.:.|     |:..||:..||....|
Human   852 IFEPVSPIKEAPGTTFVPVTDLEPVTFRTEIPATTLATKTSKRTRPPRPRPKTTPSPQAPETKPV 916

  Fly   443 ---------------------------------KNVPKQESP----------------------- 451
                                             |..|:.|:|
Human   917 PATVLEPVTLRPEASTTLASKTSQRTRRPRLRTKTTPRPEAPESKPVPTAELKPVTLRTETWVTT 981

  Fly   452 --PQSAPKQDSP---PKGAPKQDSP-PKGAPKQDSPP----KGAPK-------------QDSAPQ 493
              |:::.:...|   .|..|..:.| .|..|..|..|    ..|||             :...|:
Human   982 QAPKTSQRTRRPRPKTKTTPSPEVPQTKLVPSTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKFPE 1046

  Fly   494 QKTPPPVKQEVAPAKQDEPPAKQDAPPAKQ-------------DAP------------------- 526
            ....|..::...|..:.:..:..:.|..|.             |||
Human  1047 TTLAPKTQRTRRPRPRPKTTSSPEVPQNKSVSVTGFEPVVHSTDAPGTTFALTELQTLILKPVTS 1111

  Fly   527 --------VPVPEVIK--TLAPEVPNVSQAPAQ-----PQGQAALASEKP----ADAPKAIEEPK 572
                    .||.:|::  ||:.|.|..:.|||:     |..:|.|..|:|    .::...:.||.
Human  1112 PSLEMTESQPVSDVLESVTLSTESPKETIAPAKTDYVYPTAKAPLWPEEPKTEVVESITYVSEPP 1176

  Fly   573 AAPKKESP-------------PPTKPVTATVPVAPATPAEAPSPLAPSTPP---------STPTS 615
            ....:.||             |.|:|.....|.||..|..:|.|..|.|.|         :.|.:
Human  1177 ETTLETSPLPSQSITLPSPDEPQTEPAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKT 1241

  Fly   616 VPPSAATVTPPSPATVTPP---------SPAVVTP------PQKQSAAP---------------- 649
            .|....:.|.|:|..|..|         |..|:.|      |.|.:.||
Human  1242 SPSPEVSYTTPAPKDVLLPHKPYPEVSQSEPVLQPVTFRFEPPKTTIAPLETRGIPFIPMISPSP 1306

  Fly   650 -----QAGIKKQEAGTK-------------------------TKQQQPANKPQ----------QP 674
                 |..:::.:..|:                         |.:.:.::||.          :|
Human  1307 SQEELQTTLEETDQSTQEPFTTKIPRTTELAKTTQAPHRFYTTVRPRTSDKPHIRPVLNRTTTRP 1371

  Fly   675 QKQPPGGAGGSAGPGGNKGVQKQPNPN-AKPAVAPKPAQATPKPAAASPKASPNQTNPQQQQGKA 738
            .:..|.|.  .:|.|...||::.|.|: |...|:......|.||....|...|..|:|::
Human  1372 TRPKPSGM--PSGNGVGTGVKQAPRPSGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRR----- 1429

  Fly   739 ANKASPPKQTGPTGGQQKSAANASKATASPKSAASPKATSPKAGT-----------PTNPAS 789
              |..||...  ||....:...:|....:|...::|:.|    ||           ||.|||
Human  1430 --KPLPPNNV--TGKPGSAGIISSGPITTPPLRSTPRPT----GTPLERIETDIKQPTVPAS 1483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11835	NP_001259835.1	NAC	38..91	CDD:280093	11/57 (19%)
ABI3BP	NP_001362476.1	FN3	117..195	CDD:214495
		PHA03247	<257..580	CDD:223021	35/173 (20%)
		PHA03247	<471..973	CDD:223021	109/523 (21%)
		PHA03247	<771..1268	CDD:223021	101/501 (20%)
		PRK10263	<1151..>1403	CDD:236669	49/253 (19%)
		FN3	1550..1641	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000