DRSC/TRiP Functional Genomics Resources

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Protein Alignment rempA and IFT140

DIOPT Version :10

Sequence 1:NP_995608.1 Gene:rempA / 33230 FlyBaseID:FBgn0260933 Length:1503 Species:Drosophila melanogaster
Sequence 2:NP_055529.2 Gene:IFT140 / 9742 HGNCID:29077 Length:1462 Species:Homo sapiens


Alignment Length:1502 Identity:503/1502 - (33%)
Similarity:793/1502 - (52%) Gaps:174/1502 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTLYFDTKIEFLDSDAVSTISSWHPSEPLFAVASFSPERGGSVTIFADTGE--PQRDVTYPVHAT 63
            |.||:|.:||..|:....:..||||..|..|||..|....|||.|:.:.||  |...|..|....
Human     1 MALYYDHQIEAPDAAGSPSFISWHPVHPFLAVAYISTTSTGSVDIYLEQGECVPDTHVERPFRVA 65

  Fly    64 SQATALCWHPEKALLASGWEHGDIHVWFAGHREFASVNAPHKAAIVLLQFSEQGGRMVTADAMGL 128
            |    |||||.:.:||.|||.|::.|:....:|..::...|.|.|.:|::|..|..:::.|.:|:
Human    66 S----LCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMPLTHTADITVLRWSPSGNCLLSGDRLGV 126

  Fly   129 VTGWRCD--GQYQFLTMFSHDLREVLLLICFRLTVESEVREEMANLAKAAVAGDENALDTLTNWR 191
            :..||.|  |:.|...:..|:..:.|....|||....   |::..||||||:|||.||| :.||:
Human   127 LLLWRLDQRGRVQGTPLLKHEYGKHLTHCIFRLPPPG---EDLVQLAKAAVSGDEKALD-MFNWK 187

  Fly   192 PRTAARSMTHSGVRDNHCFYACTQGGVVYYINQGGACVEVMKCGSLPPIVQMLWH-PRKDAVICL 255
             ::::.|:...|..:...|:.....|.|:|:::.|...:|:...|   .:|||:: .:::|::.:
Human   188 -KSSSGSLLKMGSHEGLLFFVSLMDGTVHYVDEKGKTTQVVSADS---TIQMLFYMEKREALVVV 248

  Fly   256 MEDLTVTLFLVESTGILTELDRVKMSGRGGGRQGGIAWSGNSLAIITGDFFVRIWDIERSDNYLL 320
            .|:|.::|:.|...|...|:.:||:||:.|.|.......|:.|.:..|:..:|.|||||.:||:|
Human   249 TENLRLSLYTVPPEGKAEEVMKVKLSGKTGRRADIALIEGSLLVMAVGEAALRFWDIERGENYIL 313

  Fly   321 KMDLPSGNQPGSSMTTLSNGTMSSSNQFFSHDSSESSGVLRKTPKYGQLNGEMFTCLAYSSTGQT 385
            ..|                                        .|:|...||...|:.|......
Human   314 SPD----------------------------------------EKFGFEKGENMNCVCYCKVKGL 338

  Fly   386 LCAGTSQGNVYTWKRSGSRLVGAP----EDAWQLTNISSVRGAIRSCEWGYNELAKPCMLVNCLS 446
            |.|||.:|.|..|::... .:|:|    :|.|.|...:.::|.|...:||..   |..:.||.:.
Human   339 LAAGTDRGRVAMWRKVPD-FLGSPGAEGKDRWALQTPTELQGNITQIQWGSR---KNLLAVNSVI 399

  Fly   447 NVFMLKEQPLLAVHTRELWAVQRSAKSVQLTHCS-GREAIVQSEFAVTAMALSELSLVMSNGRSI 510
            :|.:|.|:.:.:...:::.|:|.|...:.:...| |....::::..::.:..::.::.:.|||.:
Human   400 SVAILSERAMSSHFHQQVAAMQVSPSLLNVCFLSTGVAHSLRTDMHISGVFATKDAVAVWNGRQV 464

  Fly   511 SSYSLQKVEKSLDEFEEILQTVEGTTPTTESTTTPLSLKLLQTFAAECLALNLCNQNIFCLGSSD 575
            :.:.|                            :..:::...||..|...|.:..:|::.:.|:.
Human   465 AIFEL----------------------------SGAAIRSAGTFLCETPVLAMHEENVYTVESNR 501

  Fly   576 VFVYSVGGVVLHRIQASDIEGKIIGMDLSGCYLSVFTMNGYVKAYDVSRHDPKLLFPSKSGHDIF 640
            |.|.:..|.|...:..|:.||....:|:.|.:|.|.|...:.|::|:||.:.|.....:|..::.
Human   502 VQVRTWQGTVKQLLLFSETEGNPCFLDICGNFLVVGTDLAHFKSFDLSRREAKAHCSCRSLAELV 566

  Fly   641 DDFGEFILVKCNSSGSHLAMVIASSNFTPISTLFCWDFE---------------RSNLLEYGLLE 690
            ...|....::|:||||.::::.:.::.:|.|.:..:|.|               |...|.:.  |
Human   567 PGVGGIASLRCSSSGSTISILPSKADNSPDSKICFYDVEMDTVTVFDFKTGQIDRRETLSFN--E 629

  Fly   691 PETN-----AKKESSTSLPVRIFWDAEEPRLLATEVKSMIQKTLPQKNSLQP------------- 737
            .|||     ..:.....:||..|||..||||...|......::.||..:.||             
Human   630 QETNKSHLFVDEGLKNYVPVNHFWDQSEPRLFVCEAVQETPRSQPQSANGQPQDGRAGPAADVLI 694

  Fly   738 ----------------------SHFVQSKVVLLFYSEKGCLNVLETQSMSPGCQLLNLCVPNVIR 780
                                  ||.:....|..:|..:..........:.|||.    .:|.:: 
Human   695 LSFFISEEHGFLLHESFPRPATSHSLLGMEVPYYYFTRKPEEADREDEVEPGCH----HIPQMV- 754

  Fly   781 LKINTMEEQPLQDFVDLQQCNPVTRKQVLNFSLYVAEGNMDMAYRSIRSIQSKVIWTNLAKMCVH 845
                  ..:||:|||.|:.|:..||..:|:||.:|..|:||.|::||:.|:|:.:|.|:|:|||.
Human   755 ------SRRPLRDFVGLEDCDKATRDAMLHFSFFVTIGDMDEAFKSIKLIKSEAVWENMARMCVK 813

  Fly   846 TNRLDVAKVCMGHLEQARSVRALRQAIEDDDLETEAKVAVLAIELGMIEEAKDLYRRCKRFDLLN 910
            |.||||||||:|::..||..||||:|.::.:|  ||:|||||.:|||:|:|:.|||:|||.||||
Human   814 TQRLDVAKVCLGNMGHARGARALREAEQEPEL--EARVAVLATQLGMLEDAEQLYRKCKRHDLLN 876

  Fly   911 KLLQSIGHLDEAVELAEAEDRIHLKHTYYQKAQELRERGDIKGALEYFEKTQNPAQNITQLLLEN 975
            |..|:.|...||:::||..||:||:.||::.|..|....|...||.|:||:......:.::|.|:
Human   877 KFYQAAGRWQEALQVAEHHDRVHLRSTYHRYAGHLEASADCSRALSYYEKSDTHRFEVPRMLSED 941

  Fly   976 PGAMKRYIQTTSDPKLLKWWGQYIESSGDMDAALAVYHKAEDWFSQVKILCYLGKISKADAIARQ 1040
            ..:::.|:....|..|.:||.||:||.|:|||||..|..|.|.||.|:|.|:.|.:.||..||.:
Human   942 LPSLELYVNKMKDKTLWRWWAQYLESQGEMDAALHYYELARDHFSLVRIHCFQGNVQKAAQIANE 1006

  Fly  1041 SGDRAACYHLARHYENVGKFQEAIMFFTRAQTFSNAIRICKENDFQEELWTVASSSRQRDKAIAA 1105
            :|:.||.|||||.||:..:..:|:.|:||||.|.||||:||||...::|..:|..|...|...||
Human  1007 TGNLAASYHLARQYESQEEVGQAVHFYTRAQAFKNAIRLCKENGLDDQLMNLALLSSPEDMIEAA 1071

  Fly  1106 AYFEECG-NFKHAVELYHRAGMLHKALEMAFESQQPEILEIIASDLAPDSDAELINRCADFFCSI 1169
            .|:||.| ....||.|||:||...||||:||.:||...|::||.||...||..|:.||:|||...
Human  1072 RYYEEKGVQMDRAVMLYHKAGHFSKALELAFATQQFVALQLIAEDLDETSDPALLARCSDFFIEH 1136

  Fly  1170 EQFQKAVHLLAKTRHLERALGICSEKGVPVTEELSEMLTPEK--GEFEEATRVHILVQLGEFLQQ 1232
            .|:::||.||...|..:.||.:|..:.:.:|||::|.:|..|  .:..|.:|..:|.|:.:...:
Human  1137 SQYERAVELLLAARKYQEALQLCLGQNMSITEEMAEKMTVAKDSSDLPEESRRELLEQIADCCMR 1201

  Fly  1233 QGDYHSATKKFTQAGDKIRAMKSLLKSGNTDKIIFFANMSRQREVYIMAANYLQALDWQSDPQVL 1297
            ||.||.||||:||||:|::||::|||||:|:||.|||::|||:|:|||||||||:|||:.:|:::
Human  1202 QGSYHLATKKYTQAGNKLKAMRALLKSGDTEKITFFASVSRQKEIYIMAANYLQSLDWRKEPEIM 1266

  Fly  1298 KHIVTFYTKGQAFDSLANFYAICAQIEIEEFQDYGKALTAMQEASKCLEKLSHAQHV-----YNN 1357
            |:|:.|||||:|.|.||.||..|||:||:|:|:|.||..|:.||.|||.|......:     ...
Human  1267 KNIIGFYTKGRALDLLAGFYDACAQVEIDEYQNYDKAHGALTEAYKCLAKAKAKSPLDQETRLAQ 1331

  Fly  1358 LQRTVADVKAILEIQQALREGDHQLVIGSCRSMLIKPEL-PPIRHAHILAMLIRALVYVKDYSEA 1421
            ||..:|.||..::.::...| |.:..|..|..:|.:|:| ..||...:...|:...|..::|..|
Human  1332 LQSRMALVKRFIQARRTYTE-DPKESIKQCELLLEEPDLDSTIRIGDVYGFLVEHYVRKEEYQTA 1395

  Fly  1422 GRALKEL 1428
            .|.|:|:
Human  1396 YRFLEEM 1402

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rempANP_995608.1 WD40 <13..147 CDD:441893 46/137 (34%)
WD40 repeat 67..103 CDD:293791 13/35 (37%)
WD40 repeat 108..144 CDD:293791 11/37 (30%)
WD40 repeat 153..202 CDD:293791 19/48 (40%)
WD40 repeat 222..276 CDD:293791 13/54 (24%)
WD40 repeat 288..312 CDD:293791 5/23 (22%)
BepA 813..927 CDD:443813 60/113 (53%)
TPR 871..1124 CDD:440225 115/253 (45%)
TPR repeat 937..973 CDD:276809 10/35 (29%)
TPR repeat 988..1039 CDD:276809 26/50 (52%)
TPR repeat 1044..1070 CDD:276809 12/25 (48%)
IFT140NP_055529.2 WD 1 4..48 18/43 (42%)
WD40 repeat 19..59 CDD:293791 16/39 (41%)
WD40 <24..133 CDD:441893 40/112 (36%)
WD 2 51..90 17/42 (40%)
WD40 repeat 65..101 CDD:293791 14/39 (36%)
WD 3 93..132 10/38 (26%)
WD40 repeat 106..144 CDD:293791 11/37 (30%)
WD 4 139..188 21/53 (40%)
WD40 repeat 152..197 CDD:293791 20/49 (41%)
WD40 repeat 204..258 CDD:293791 14/56 (25%)
WD 5 221..259 10/40 (25%)
WD 6 266..305 12/38 (32%)
WD40 repeat 268..320 CDD:293791 20/91 (22%)
WD 7 322..361 12/39 (31%)
WD40 repeat 327..351 CDD:293791 8/23 (35%)
TPR 1 772..807 15/34 (44%)
TPR repeat 803..837 CDD:276809 20/33 (61%)
LapB <834..1082 CDD:442196 114/249 (46%)
TPR repeat 842..872 CDD:276809 18/31 (58%)
TPR 2 869..904 18/34 (53%)
TPR 3 906..934 8/27 (30%)
TPR 4 955..988 18/32 (56%)
LapB 973..>1227 CDD:442196 114/253 (45%)
TPR 5 1010..1043 17/32 (53%)
TPR 6 1078..1111 16/32 (50%)
TPR 7 1123..1156 12/32 (38%)
TPR 8 1189..1222 15/32 (47%)
TPR 9 1376..1409 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1434..1462
Blue background indicates that the domain is not in the aligned region.

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