DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rempA and Ift140

DIOPT Version :10

Sequence 1:NP_995608.1 Gene:rempA / 33230 FlyBaseID:FBgn0260933 Length:1503 Species:Drosophila melanogaster
Sequence 2:XP_038943020.1 Gene:Ift140 / 100362124 RGDID:2318759 Length:1468 Species:Rattus norvegicus


Alignment Length:1521 Identity:521/1521 - (34%)
Similarity:822/1521 - (54%) Gaps:160/1521 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTLYFDTKIEFLDSDAVSTISSWHPSEPLFAVASFSPERGGSVTIFADTGEPQRDVTYPVHATSQ 65
            |.||||.:|:..|:.:..:..:|||:.|..||||.||..||:|.|:.:.|||..|.  .:..:.|
  Rat     1 MALYFDHRIKAPDASSSPSHITWHPTHPFLAVASVSPSSGGNVDIYLEQGEPVPDT--HIERSFQ 63

  Fly    66 ATALCWHPEKALLASGWEHGDIHVWFAGHREFASVNAPHKAAIVLLQFSEQGGRMVTADAMGLVT 130
            ||:|||||.:.:||.|||.|::.::....:|..:|..||...|.:|.:|..|..:|:.|.:|::.
  Rat    64 ATSLCWHPTRLILAIGWETGEVIMFNKQDKEQHTVPLPHTTDIAILSWSTSGSCLVSGDKLGVLL 128

  Fly   131 GWRCD--GQYQFLTMFSHDLREVLLLICFRLTVESEVREEMANLAKAAVAGDENALDTLTNWRPR 193
            .||.|  |:.|...:..|:..:.|....|||....   |::..||||||:|||.||| :.||| :
  Rat   129 LWRLDQRGRVQGTPLLKHEYGKPLTHCIFRLPPPG---EDLVQLAKAAVSGDEKALD-MFNWR-K 188

  Fly   194 TAARSMTHSGVRDNHCFYACTQGGVVYYINQGGACVEVMKCGSLPPIVQMLWH-PRKDAVICLME 257
            ::..|...:|.::...|:.....|.|:|:::.|...:|   .|....:|.|:: .:::|::.:.:
  Rat   189 SSFGSFLKTGSQEGLSFFVSLMDGTVHYVDEKGKTAQV---ASTDSSIQTLFYIEKREALVVVTQ 250

  Fly   258 DLTVTLFLVESTGILTELDRVKMSGRGGGRQGGIAWSGNSLAIITGDFFVRIWDIERSDNYLLKM 322
            :|.::|::|...|...|:.:||:||:.|.|.......|:.|....|:..:|.||:||.:||:|.:
  Rat   251 NLLLSLYVVNPEGEAEEVMKVKLSGKTGRRADITLIEGSLLVTAIGEPVLRFWDLERGENYILSL 315

  Fly   323 DLPSGNQPGSSMTTLSNGTMSSSNQFFSHDSSESSGVLRKTPKYGQLNGEMFTCLAYSSTGQTLC 387
            .                                        .|:|...||....:.|......|.
  Rat   316 Q----------------------------------------EKFGFEKGENINSVCYCKAKGLLA 340

  Fly   388 AGTSQGNVYTWKR-----SGSRLVGAPEDAWQLTNISSVRGAIRSCEWGYNELAKPCMLVNCLSN 447
            |||.:|.|..||:     ||....|  :|.|.|...:.:.|.|...:||..   |..:.|:...:
  Rat   341 AGTHKGRVAMWKKVPVSPSGRGAEG--KDMWALQTPTELEGNITQIKWGSR---KNLLAVSTSDS 400

  Fly   448 VFMLKEQPLLAVHTRELWAVQRSAKSVQLTHCS-GREAIVQSEFAVTAMALSELSLVMSNGRSIS 511
            |.:|.||.:.:...:::.|||.|...|.::..| |....::::..::.:..::.::.:.||:.::
  Rat   401 VSILSEQAMSSHFHQQVAAVQISPSLVNVSFLSTGSTHSLRTDMHISGVFATKDAVAVWNGKQVA 465

  Fly   512 SYSLQKVEKSLDEFEEILQTVEGTTPTTESTTTPLSLKLLQTFAAECLALNLCNQNIFCLGSSDV 576
            .:     |.|            |:|           |:...||..|...|.:..::|:.:..:.:
  Rat   466 IF-----EPS------------GST-----------LRNAGTFLCETSVLAMHEESIYTVEPNRL 502

  Fly   577 FVYSVGGVVLHRIQASDIEGKIIGMDLSGCYLSVFTMNGYVKAYDVSRHDPKLLFPSKSGHDIFD 641
            .|.:..|.|...:..|:.||....:|:.|.:|...|...:.|::|:||.:.|:....|:...:..
  Rat   503 QVRTWQGTVKQLLLFSETEGSPCFLDVCGTFLVAGTDLAHFKSFDLSRREAKVHCSCKNLAQMIP 567

  Fly   642 DFGEFILVKCNSSGSHLAMVIASSNFTPISTLFCWDFERS--NLLEY-----GLL------EPET 693
            |.|....::||::|:.::::::..:.:|.|.::.:|.|..  |:..:     |.:      ||.|
  Rat   568 DVGSITSLRCNANGNKISILLSKVDNSPDSKIYVYDVEMDTVNVFNFKTGHIGQIQTLPFNEPPT 632

  Fly   694 NA----KKESSTS-LPVRIFWDAEEPRLLATEVKSMIQKTLPQKNSLQPSHFVQSK------VVL 747
            |.    ..||..| :||..|||..||||...|.........||....|| |..:..      ::|
  Rat   633 NEAHFFMNESLASYVPVNHFWDQSEPRLFVCEALQEAPGAQPQAIDKQP-HMEEGTCHKEEVLIL 696

  Fly   748 LFYS--EKGCLNVLETQSMSPGC--QLLNLCVPNVIRLK------------------INTMEEQP 790
            .|::  |.|.|  |......|..  .||.|.||:....|                  ...:.::|
  Rat   697 SFFASEEHGFL--LHDSFPRPSTYQSLLGLEVPHYYFTKKPGEADKEDKMDSGHYHIPQMVAKKP 759

  Fly   791 LQDFVDLQQCNPVTRKQVLNFSLYVAEGNMDMAYRSIRSIQSKVIWTNLAKMCVHTNRLDVAKVC 855
            |:|||.|:.|:..||..:||||.:|..|:||.|::||:.|:|:.:|.|:|:|||.|.||||||||
  Rat   760 LRDFVGLEDCDKPTRDAMLNFSFFVTIGDMDEAFKSIKLIKSETVWENMARMCVKTQRLDVAKVC 824

  Fly   856 MGHLEQARSVRALRQAIEDDDLETEAKVAVLAIELGMIEEAKDLYRRCKRFDLLNKLLQSIGHLD 920
            :|::..||..||||:|..:.:|  ||:||:|||:|||:|||:.||::|||:|||||..|:.....
  Rat   825 LGNMGHARGARALREAEREPEL--EARVAMLAIQLGMLEEAEQLYKKCKRYDLLNKFYQASDQWQ 887

  Fly   921 EAVELAEAEDRIHLKHTYYQKAQELRERGDIKGALEY-----FEKTQNPAQNITQLLLENPGAMK 980
            :|||:||..||:||:.|||..|:.|....|...||.|     :||:......:.::|.|:..:::
  Rat   888 KAVEVAELHDRVHLRTTYYNYAKHLEASADCGLALSYSFFHSYEKSDTHRFEVPRMLSEDLQSLE 952

  Fly   981 RYIQTTSDPKLLKWWGQYIESSGDMDAALAVYHKAEDWFSQVKILCYLGKISKADAIARQSGDRA 1045
            .||....|..|.:||.||:||..:||.||..|..|:|:||.|:|.|:.|.|.||..||.::||.|
  Rat   953 LYINRMKDKTLWRWWAQYLESQAEMDTALRYYELAQDYFSLVRIHCFQGNIQKAAEIANETGDWA 1017

  Fly  1046 ACYHLARHYENVGKFQEAIMFFTRAQTFSNAIRICKENDFQEELWTVASSSRQRDKAIAAAYFEE 1110
            |.|||||.||:..:.::|:.|:||||.|:||||:||||...::|..:|..|...|...||.|:||
  Rat  1018 ASYHLARQYESQDEVKQAVHFYTRAQAFNNAIRLCKENGLDDQLMNLALLSSPEDMIEAARYYEE 1082

  Fly  1111 CG-NFKHAVELYHRAGMLHKALEMAFESQQPEILEIIASDLAPDSDAELINRCADFFCSIEQFQK 1174
            .| ....||.|||:||...||||:||.:||...|::||.||...||..|:.||:||.....||:|
  Rat  1083 KGEQMDRAVMLYHKAGHFSKALELAFTTQQFAALQLIAEDLDEKSDPALLARCSDFCIEHRQFEK 1147

  Fly  1175 AVHLLAKTRHLERALGICSEKGVPVTEELSEMLTPEKG--EFEEATRVHILVQLGEFLQQQGDYH 1237
            ||.||...:....||.:|.|:.:.:|||::|.:|..|.  :..|.:|..:|.|:.....:||:||
  Rat  1148 AVELLLAAKKYHEALQLCLEQNMTITEEMAEKMTVSKDSKDLSEESRRELLEQIANCCMRQGNYH 1212

  Fly  1238 SATKKFTQAGDKIRAMKSLLKSGNTDKIIFFANMSRQREVYIMAANYLQALDWQSDPQVLKHIVT 1302
            .||||:||||:|::||::|||||:|:||:|||.:|||:|:|||||||||:|||:.:|:::|:|::
  Rat  1213 LATKKYTQAGNKLKAMRALLKSGDTEKIVFFAGVSRQKEIYIMAANYLQSLDWRKEPEIMKNIIS 1277

  Fly  1303 FYTKGQAFDSLANFYAICAQIEIEEFQDYGKALTAMQEASKCLEKLSHAQHVYN------NLQRT 1361
            |||||:|.|.||.||..|||:||:|:|:|.||..|:.||.|||.| :.|::..:      .||..
  Rat  1278 FYTKGRALDLLAGFYDACAQVEIDEYQNYDKAHGALTEAYKCLSK-AKAKNPLDQETKLAQLQSK 1341

  Fly  1362 VADVKAILEIQQALREGDHQLVIGSCRSMLIKPEL-PPIRHAHILAMLIRALVYVKDYSEAGRAL 1425
            :..||..::.::...| |.:..:..|..:|.:|:| ..||...|...|:...|.:::|..|.:.|
  Rat  1342 MTLVKRFIQARRTYTE-DPKESVRQCELLLEEPDLDSTIRVGDIYGFLVEHHVQMEEYQMAYKYL 1405

  Fly  1426 KELTVKDSTWSASGLLDRSIVHKIAQ 1451
            :|:..:..:.:.|..:|:..|..:.|
  Rat  1406 EEMRKRLPSANMSYYVDQRTVDTVHQ 1431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rempANP_995608.1 WD40 <13..147 CDD:441893 49/135 (36%)
WD40 repeat 67..103 CDD:293791 14/35 (40%)
WD40 repeat 108..144 CDD:293791 12/37 (32%)
WD40 repeat 153..202 CDD:293791 20/48 (42%)
WD40 repeat 222..276 CDD:293791 11/54 (20%)
WD40 repeat 288..312 CDD:293791 5/23 (22%)
BepA 813..927 CDD:443813 60/113 (53%)
TPR 871..1124 CDD:440225 117/258 (45%)
TPR repeat 937..973 CDD:276809 11/40 (28%)
TPR repeat 988..1039 CDD:276809 25/50 (50%)
TPR repeat 1044..1070 CDD:276809 12/25 (48%)
Ift140XP_038943020.1 WD40 <15..133 CDD:441893 45/119 (38%)
WD40 repeat 19..57 CDD:293791 18/39 (46%)
WD40 repeat 64..101 CDD:293791 15/36 (42%)
WD40 repeat 108..160 CDD:293791 15/51 (29%)
LapB 825..1042 CDD:442196 97/218 (44%)
LapB <968..1155 CDD:442196 92/186 (49%)

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