DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ets21C and FEV

DIOPT Version :9

Sequence 1:	NP_001285547.1	Gene:	Ets21C / 33229	FlyBaseID:	FBgn0005660	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_059991.1	Gene:	FEV / 54738	HGNCID:	18562	Length:	238	Species:	Homo sapiens

Alignment Length:	235	Identity:	103/235 - (43%)
Similarity:	117/235 - (49%)	Gaps:	77/235 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 VAQGSGGQIQLWQFLLELLADSSNANAISWEGQSGEFRLIDPDEVARRWGERKAKPNMNYDKLSR 311
            |.:|| |||||||||||||||.:||..|:|||..|||:|.|||||||||||||:|||||||||||
Human    40 VQKGS-GQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSR 103

  Fly   312 ALRYYYDKNIMTKVHGKRYAYKFDFHGLMAACQAQAQGGDPASSMLGSYNHHAGGAMQLGRHPPP 376
            |||||||||||:|||||||||:|||.||..|||                             |||
Human   104 ALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQ-----------------------------PPP 139

  Fly   377 LHHHPQHSHPHHQLGQPHFLHPHHSSPASNSSSLGFPSSSTASSQASPGQAPASSSASTSNFTAP 441
            .|.|                                 :::.|::.|:..|..|...........|
Human   140 AHAH---------------------------------AAAAAAAAAAAAQDGALYKLPAGLAPLP 171

  Fly   442 FQG--------GTAGVDPARTSTSSAGNYDQGPVTPTTNA 473
            |.|        .:|||.||..|      |..||....|.|
Human   172 FPGLSKLNLMAASAGVAPAGFS------YWPGPGPAATAA 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets21C	NP_001285547.1	SAM_PNT	149..217	CDD:188876
Ets21C	NP_001285547.1	ETS	254..339	CDD:197710	71/84 (85%)
FEV	NP_059991.1	ETS	46..131	CDD:197710	71/84 (85%)
FEV	NP_059991.1	May mediate active transcriptional repression	129..238		28/145 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3806
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1113327at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3711
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.810