Protein Alignment Ets21C and ELK1

DIOPT Version :10

• Sequence 1: NP_523445.1
• Gene: Ets21C / 33229
• FlyBaseID: FBgn0005660
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_005220.2
• Gene: ELK1 / 2002
• HGNCID: 3321
• Length: 428
• Species: Homo sapiens
• Alignment Length: 229
• Identity: 82/229 - (35%)
• Similarity: 107/229 - (46%)
• Gaps: 52/229 - (22%)

  Fly   255 IQLWQFLLELLADSSNANAISWEGQ-SGEFRLIDPDEVARRWGERKAKPNMNYDKLSRALRYYYD 318
            :.||||||:||.:..|.:.|||..: .|||:|:|.:||||.||.||.|.||||||||||||||||
Human     5 VTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYD 69

  Fly   319 KNIMTKVHGKRYAYKFDFHGLMAACQAQ-----------------------AQGGDPASSMLGSY 360
            |||:.||.|:::.|||..:..:|.|..:                       |..||..|...|:
Human    70 KNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIHAAPGDTVSGKPGT- 133

  Fly   361 NHHAGGAMQLGRHPPPLHHHPQHSHPHHQL----------GQPHFLHPHHSSPASNSSSLGFPSS 415
               ..||...|  |..|....::.:....|          .||    |.|..||     :..||:
Human   134 ---PKGAGMAG--PGGLARSSRNEYMRSGLYSTFTIQSLQPQP----PPHPRPA-----VVLPSA 184

  Fly   416 STASSQASPGQAPASSSASTSNFTAPFQGGTAGV 449
            :.|.:.|.|.   .|.|.|.|...|..:...||:
Human   185 APAGAAAPPS---GSRSTSPSPLEACLEAEEAGL 215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ets21C	NP_523445.1	SAM_PNT	149..217	CDD:188876
		ETS	254..339	CDD:197710	51/84 (61%)
ELK1	NP_005220.2	ETS	4..89	CDD:197710	51/83 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..149		10/33 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..205		15/51 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	228..358
		Sufficient for interaction with MAD2L2. /evidence=ECO:0000269|PubMed:17296730	349..399