DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ets21C and Erg

DIOPT Version :9

Sequence 1:	NP_001285547.1	Gene:	Ets21C / 33229	FlyBaseID:	FBgn0005660	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	XP_038943856.1	Gene:	Erg / 170909	RGDID:	621108	Length:	486	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	157/493 - (31%)
Similarity:	205/493 - (41%)	Gaps:	154/493 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QSHKQLPIISQTIRSAWCQQRPINAMHQDVRQKSIGSGNETKLEAKETEVPTNRRRRRRRCSSSS 73
            |:.|..|.:.|   ..|..|.|...              ..|:|...::|..:|.      |...
  Rat    50 QTSKMSPRVPQ---QDWLSQPPARV--------------TIKMECNPSQVNGSRN------SPDE 91

  Fly    74 TSDSSASSYSSTDSDSGSSTSSSSIRSQLPALNLPVPLPLATPTPPAVSSPHQAPSPRRNSSDSN 138
            .|.:.......:....|.|..|......:|                   .|:...:.||
  Rat    92 CSVTKGGKMVGSPDTVGMSYGSYMEEKHMP-------------------PPNMTTNERR------ 131

  Fly   139 RSVSPVEVPVDPHAWTPEDIASWVRWATRKFKLDPEPDIDRFPK-DAQELCDLSRADFWVCAGSR 202
                 |.||.||..|:.:.:..|:.||.:::.| .:.|:..|.. |.:|||.:::.||.....|.
  Rat   132 -----VIVPADPTLWSTDHVRQWLEWAVKEYGL-LDVDVLLFQNIDGKELCKMTKDDFQRLTPSY 190

  Fly   203 RGGMLLAQ-HF--------------------AISLYHA--------------------------- 219
            ...:||:. |:                    :..|.||
  Rat   191 NADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRP 255

  Fly   220 ------------TGR--------------ETSPMLNDDEP--NPYQLLNAASHRLVAQGSGGQIQ 256
                        ||.              .|.|...|..|  :|||:|...|.||...|| ||||
  Rat   256 DLPYEPPRRSTWTGHSHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGS-GQIQ 319

  Fly   257 LWQFLLELLADSSNANAISWEGQSGEFRLIDPDEVARRWGERKAKPNMNYDKLSRALRYYYDKNI 321
            |||||||||:||||:|.|:|||.:|||::.|||||||||||||:|||||||||||||||||||||
  Rat   320 LWQFLLELLSDSSNSNCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNI 384

  Fly   322 MTKVHGKRYAYKFDFHGLMAACQAQAQGGDPASSM---------LGSYNHHAGGAMQLGRHPPPL 377
            |||||||||||||||||:..|.|..    .|.||:         :|||:.|......:..|||.|
  Rat   385 MTKVHGKRYAYKFDFHGIAQALQPH----PPESSLYKYPSDLPYMGSYHTHPQKMNFVAPHPPAL 445

  Fly   378 HHHPQHSHPHHQLGQPHF------LHPHHSSPASNSSS 409
               |..|........|::      ::|:...|||:..|
  Rat   446 ---PVTSSSFFATPNPYWNSPTGGIYPNTRLPASHMPS 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets21C	NP_001285547.1	SAM_PNT	149..217	CDD:188876	19/89 (21%)
Ets21C	NP_001285547.1	ETS	254..339	CDD:197710	74/84 (88%)
Erg	XP_038943856.1	SAM_superfamily	122..205	CDD:417767	25/94 (27%)
Erg	XP_038943856.1	ETS	317..400	CDD:197710	72/82 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3556
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1113327at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11849
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.070