DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta3 and HTR3B

DIOPT Version :9

Sequence 1:NP_525098.1 Gene:nAChRbeta3 / 33228 FlyBaseID:FBgn0031261 Length:441 Species:Drosophila melanogaster
Sequence 2:NP_006019.1 Gene:HTR3B / 9177 HGNCID:5298 Length:441 Species:Homo sapiens


Alignment Length:480 Identity:111/480 - (23%)
Similarity:186/480 - (38%) Gaps:103/480 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 LLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGT-PTNVSLEMV 82
            :|..:|..|...:....|..|| |..:....||..|...|...|..:|:||:..| .|.|.|::.
Human     1 MLSSVMAPLWACILVAAGILAT-DTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLF 64

  Fly    83 V-TYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGGLM 146
            | ..:|:|..|..|.|..|....|.||...|..|.:|.|.:|:|..|.:|.|.|         ::
Human    65 VHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDI---------II 120

  Fly   147 AE----------TQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPEN 201
            .|          ..|.::..|......|....:.|.|....:|.|.|:|.|...|....|...:.
Human   121 NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDL 185

  Fly   202 GTARG-ESLDHDD--LVQSPEWEIVDSRAHFVSQDY---------YGYMEYTLTAQRRSSMYTAV 254
            ...|. |.:.||.  .:...|||::.     ||..|         :..:::.:..:|...:|...
Human   186 AFLRSPEDIQHDKKAFLNDSEWELLS-----VSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVS 245

  Fly   255 IYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTS 319
            :..|:..::::.|.:|:|||:... :|:....:::....|.:..:..:|....:|||:..|::..
Human   246 LLIPSIFLMLVDLGSFYLPPNCRA-RIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTIC 309

  Fly   320 LLYLSVSTIVE-VLVLYL-----------------ATGKHKRRL-PEALRKL-----LHG-HL-- 357
            :.:|.:|.... |||.:|                 .|...:.|: |.|.|.:     |:| ||  
Human   310 MAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQ 374

  Fly   358 -GT----WLLLSVFSTTGESQAEKTKEMDEHPYEEADEQESSPLGINHTEVPGAKANQFDWALLA 417
             ||    |..|...|...::|            ::.|:||:                  :|.:|.
Human   375 PGTLKEVWSQLQSISNYLQTQ------------DQTDQQEA------------------EWLVLL 409

  Fly   418 TAVDRISFVSFSLAFLILAIR-CSV 441
            :..||:.|.|:.....|..|. ||:
Human   410 SRFDRLLFQSYLFMLGIYTITLCSL 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta3NP_525098.1 LIC 39..437 CDD:273305 104/453 (23%)
Neur_chan_LBD 52..247 CDD:280998 53/218 (24%)
Neur_chan_memb 255..434 CDD:280999 43/210 (20%)
HTR3BNP_006019.1 LIC 8..435 CDD:273305 109/473 (23%)
Neur_chan_LBD 33..239 CDD:280998 54/219 (25%)
Neur_chan_memb 246..>328 CDD:280999 18/82 (22%)
HA-stretch 381..413 9/61 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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