Protein Alignment nAChRbeta3 and CHRFAM7A

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_647536.1
• Gene: CHRFAM7A / 89832
• HGNCID: 15781
• Length: 412
• Species: Homo sapiens
• Alignment Length: 371
• Identity: 83/371 - (22%)
• Similarity: 147/371 - (39%)
• Gaps: 96/371 - (25%)

  Fly   149 TQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGESLD--- 210
            |.|.::..||.:::||.::.:.|.:::..:|.|.|.||||.|||          :..|.|||
Human    38 TNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSW----------SYGGWSLDLQM 92

  Fly   211 -HDDL---VQSPEWEIV------DSRAHFVSQDYYGYMEYTLTAQRRSSMYTAVIYTPASCIVIL 265
             ..|:   :.:.||::|      ..|.:...::.|..:.:|:|.:||:..|...:..|...|..|
Human    93 QEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISAL 157

  Fly   266 ALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVE 330
            ||..|.||.. .||||.:...:::.:..|::..|:::|..|::.||:..:::::::.:.:|.:|.
Human   158 ALLVFLLPAD-SGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVT 221

  Fly   331 VLVL-YLATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTGESQAE------------KTKEM-- 380
            |:|| |........::|:..|.:|.... .|.|.  ....||.:..            .:.||
Human   222 VIVLQYHHHDPDGGKMPKWTRVILLNWC-AWFLR--MKRPGEDKVRPACQHKQRRCSLASVEMSA 283

  Fly   381 -------------------------------------------DEHPYEEADEQESSPLGINHTE 402
                                                       |||........|..|......|
Human   284 VAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILE 348

  Fly   403 VPGAKANQF-----------DWALLATAVDRISFVSFSLAFLILAI 437
            .....||:|           :|...|..|||:..::||:..:|..|
Human   349 EVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTI 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	82/369 (22%)
		Neur_chan_LBD	52..247	CDD:280998	29/110 (26%)
		Neur_chan_memb	255..434	CDD:280999	49/247 (20%)
CHRFAM7A	NP_647536.1	Neur_chan_LBD	<28..400	CDD:332142	83/371 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910