Protein Alignment nAChRbeta3 and CHRNA6

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_004189.1
• Gene: CHRNA6 / 8973
• HGNCID: 15963
• Length: 494
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 113/464 - (24%)
• Similarity: 192/464 - (41%)
• Gaps: 100/464 - (21%)

  Fly    52 DRLHAGLFTNYDSDVQPVFQ-GTPTNVSLEMVVTYI-DIDELNGKLTTHCWLNLRWRDEERVWQP 114
            :||...||::|:..::||.. ..|..|..|:.:|.: ::||:|..:.|:.||...|.|.:..|.|
Human    35 ERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDP 99

  Fly   115 SQYDNITQITLKSSEVWTPQITLFNGDEGGLMAE--TQVTLSHDGHFRWMPPAVYTAYCELNMLN 177
            .:||.|..:.:.:.::|.|.|.|:|...|....|  |:..|.::|...|.|||::.:.|.:::..
Human   100 MEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITF 164

  Fly   178 WPHDKQSCKLKIGSW-------GLKVVLPENGTARGESLDHDDLVQSPEWEIVDSRA--HFVS-- 231
            :|.|.|:|.||.|||       .|.::        |..:|.:|..::.||||:|:..  |.:.
Human   165 FPFDHQNCSLKFGSWTYDKAEIDLLII--------GSKVDMNDFWENSEWEIIDASGYKHDIKYN 221

  Fly   232 --QDYYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAF 294
              ::.|..:.|:...:|....||..:..|...|..|.:..|:||... |||:.:...:::.:..|
Human   222 CCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDC-GEKVTLCISVLLSLTVF 285

  Fly   295 LMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYL----------------------- 336
            |:...:.:|..|...|||..:...:::::::|.:|.|.||.:
Human   286 LLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLP 350

  Fly   337 -------------ATGKH-----------KRRL-----PEALRKLLHGHLGTWLLLSVFSTTGES 372
                         .||..           |.:|     |..|::..|.|....|..|. ......
Human   351 QVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSK-RRLSHQ 414

  Fly   373 QAEKTKEMDEHPYEEAD---------EQESSPLGINHTEVPGAKANQFDWALLATAVDRISFVSF 428
            ..:...|..||..|..|         |...|     |.|   .|..:.||..:|..|||:    |
Human   415 PLQWVVENSEHSPEVEDVINSVQFIAENMKS-----HNE---TKEVEDDWKYVAMVVDRV----F 467

  Fly   429 SLAFLILAI 437
            ...|:|:.:
Human   468 LWVFIIVCV 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	113/462 (24%)
		Neur_chan_LBD	52..247	CDD:280998	60/211 (28%)
		Neur_chan_memb	255..434	CDD:280999	49/239 (21%)
CHRNA6	NP_004189.1	Neur_chan_LBD	34..484	CDD:332142	113/464 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910