DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta3 and Chrna1

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_077811.1	Gene:	Chrna1 / 79557	RGDID:	69277	Length:	457	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	120/469 - (25%)
Similarity:	220/469 - (46%)	Gaps:	75/469 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPV---FQGTPTNVSLEM 81
            :::...:||:||.|. |....::.:.       ||.|.||.:|.|.|:||   .:.....|.|::
  Rat     1 MELTAVLLLLGLCSA-GTVLGSEHET-------RLVAKLFKDYSSVVRPVGDHREIVQVTVGLQL 57

  Fly    82 VVTYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEG--G 144
             :..|::||:|..:||:..|..:|.|....|.|..|..:.:|.:.|.::|.|.:.|:|..:|  .
  Rat    58 -IQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFA 121

  Fly   145 LMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW----GLKVVLPENGTAR 205
            ::..|:|.|.:.||..|.|||::.:|||:.:.::|.|:|:|.:|:|:|    .:..:.||:
  Rat   122 IVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPES---- 182

  Fly   206 GESLDHDDLVQSPEWEIVDSRA--HFVSQDYYG------YME--YTLTAQRRSSMYTAVIYTPAS 260
             :..|..:.::|.||.|.::|.  |:|   :|.      |::  |....||....:...:..|..
  Rat   183 -DQPDLSNFMESGEWVIKEARGWKHWV---FYSCCPNTPYLDITYHFVMQRLPLYFIVNVIIPCL 243

  Fly   261 CIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSV 325
            ....|....|:||.. .|||:.::..:::.:..||:...:|:|..|:..||:..:...:::::..
  Rat   244 LFSFLTSLVFYLPTD-SGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIA 307

  Fly   326 STIVEVLVLYLATGKHKRR-----LPEALRKLLHGHLGTWLLLSVFSTTGESQAEK---TKEMDE 382
            |.|:.|:|:    ..|.|.     :||.:||:....:...:..|........:.||   |:::|.
  Rat   308 SIIITVIVI----NTHHRSPSTHIMPEWVRKVFIDTIPNIMFFSTMKRPSRDKQEKRIFTEDIDI 368

  Fly   383 HPYEEADEQESSPLG-----INHTEVPGA-----------KANQ------FDWALLATAVDRISF 425
            .  :.:.:....|:|     |.|.||..|           |::|      .:|..:|..:|.|..
  Rat   369 S--DISGKPGPPPMGFHSPLIKHPEVKSAIEGVKYIAETMKSDQESNNASEEWKYVAMVMDHILL 431

  Fly   426 VSFSLAFLI--LAI 437
            ..|.|..||  ||:
  Rat   432 GVFMLVCLIGTLAV 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	113/448 (25%)
		Neur_chan_LBD	52..247	CDD:280998	64/213 (30%)
		Neur_chan_memb	255..434	CDD:280999	45/208 (22%)
Chrna1	NP_077811.1	LIC	21..447	CDD:273305	114/448 (25%)
		Neur_chan_LBD	24..231	CDD:280998	65/222 (29%)
		Neur_chan_memb	238..446	CDD:280999	49/215 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48230
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920