Protein Alignment nAChRbeta3 and chrnb3a

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_957514.1
• Gene: chrnb3a / 794401
• ZFINID: ZDB-GENE-040108-1
• Length: 467
• Species: Danio rerio
• Alignment Length: 464
• Identity: 119/464 - (25%)
• Similarity: 201/464 - (43%)
• Gaps: 68/464 - (14%)

  Fly    23 LMGMLLMGLTSVPGATATADPKNANVKAL-DRLHAGLFTNYDSDVQPVFQGTPT-NVSLEMVVT- 84
            :.|:||:...:.  ||..|..:..::..: |.|...||..|...|:||.....| .|...:.::
Zfish     5 ISGILLVAAAAY--ATIEAPEEFVSLAEMEDTLLRNLFRGYQKWVRPVLHANDTITVRFGLKISQ 67

  Fly    85 YIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLF-NGD---EGGL 145
            .:|:||.|..:||:.||...|.|.:..|.|..|..||.|.:.|..:|.|.|.|: |.|   ||.|
Zfish    68 LVDVDEKNQLMTTNVWLWEEWTDYKLRWNPEDYGGITSIRVPSETIWLPDIVLYENADGRFEGSL 132

  Fly   146 MAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPENGTARGE 207
            |  |:..:..:|...|.|||.|.:.|.:::..:|.|:|:|.:|.|||   |..|.|    |....
Zfish   133 M--TKAIVRFNGTIMWTPPASYKSACTMDVTFFPFDRQNCSMKFGSWTYDGTMVDL----TLVDA 191

  Fly   208 SLDHDDLVQSPEWEIVDSRAHFVSQD----YYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALS 268
            .:|..|...:.||||:::.....|:.    .|.|:.|:...:|....||..:..|...:..|.:.
Zfish   192 YVDRKDFFDNGEWEILNATGQRGSRRDGIYSYPYLTYSFILKRLPLFYTLFLIIPCLGLSFLTVL 256

  Fly   269 AFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLV 333
            .|:||.. .|||:.::..:::.:..||:...:::|..|...||:..:....:::::.|.||.|.|
Zfish   257 VFYLPSD-EGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFV 320

  Fly   334 LYLATGKHKR------------------RLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEM 380
            :.:    |.|                  |||..|  .:.||...:....:...:.|.:....|..
Zfish   321 INV----HHRSSATYHPMAPWVKSLFLQRLPRLL--CMRGHTDRYQYPDIELRSPELKRGMKKGQ 379

  Fly   381 DEHP------YEEADEQ------ESSPLGINHTEVPGAKANQF-----DWALLATAVDRISFVSF 428
            .:..      .:|.:.|      |.:...:::......|.:..     ||..:|..:|||    |
Zfish   380 QKSAGGGRAGVKEDENQAWIALLEKATHSVHYISRHIRKEHFIREVVQDWKFVAQVLDRI----F 440

  Fly   429 SLAFLILAI 437
            ..|||.:::
Zfish   441 LWAFLTVSV 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	114/446 (26%)
		Neur_chan_LBD	52..247	CDD:280998	67/207 (32%)
		Neur_chan_memb	255..434	CDD:280999	42/213 (20%)
chrnb3a	NP_957514.1	LIC	9..459	CDD:273305	118/460 (26%)
		Neur_chan_LBD	32..236	CDD:280998	68/209 (33%)
		Neur_chan_memb	243..456	CDD:280999	43/218 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810