Protein Alignment nAChRbeta3 and Htr3a

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: XP_006243083.1
• Gene: Htr3a / 79246
• RGDID: 61818
• Length: 488
• Species: Rattus norvegicus
• Alignment Length: 500
• Identity: 122/500 - (24%)
• Similarity: 204/500 - (40%)
• Gaps: 102/500 - (20%)

  Fly    16 LPLLLQMLMGMLLMGLTSVPG---------ATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQ 71
            :||.:..::..|.:.:....|         |.:|..|      ||.||...|..||...|:||..
  Rat     1 MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQP------ALLRLSDHLLANYKKGVRPVRD 59

  Fly    72 -GTPTNVSLEMVV-TYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQ 134
             ..||.||::::: ..:::||.|..|||:.|....|.||...|.|..:||:|::::.:..:|.|.
  Rat    60 WRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPD 124

  Fly   135 ITLFNG--DEGGLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW----- 192
            | |.|.  |.|...:...|.:.|.|..:...|......|.|::.|:|.|.|:|.|...||
  Rat   125 I-LINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQ 188

  Fly   193 GLKVVL---PENGTARGESLDHDDLVQSPEWEIVDSRAHFVSQDY-------YGYMEYTLTAQRR 247
            .:.:.|   ||...:     |....:...|||::.....|  |::       |..|::.:..:||
  Rat   189 DINISLWRTPEEVRS-----DKSIFINQGEWELLGVFTKF--QEFSIETSNSYAEMKFYVVIRRR 246

  Fly   248 SSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLV 312
            ...|...:..|:..::::.:..|.|||. .||::.....|::..:.||:..:..||..:..|||:
  Rat   247 PLFYAVSLLLPSIFLMVVDIVGFCLPPD-SGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLI 310

  Fly   313 VIFYSTSLLYLSVSTIVEVLVLYLATGKHK----RRLPEALRKLLHGHLGTWLLLSVFSTTGES- 372
            .:::...:..|.:|....:.::.|.   ||    |.:|:.||.|:...: .|||     ..||.
  Rat   311 GVYFVVCMALLVISLAETIFIVQLV---HKQDLQRPVPDWLRHLVLDRI-AWLL-----CLGEQP 366

  Fly   373 ---------QAEKTKE--------MDEH--------PYEEADEQESSPL---------------- 396
                     ||.||.:        |..|        ..|:......|||
  Rat   367 MAHRPPATFQANKTDDCSGSLLPAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRGLLQE 431

  Fly   397 --GINHTEVPGAKANQF--DWALLATAVDRISFVSFSLAFLILAI 437
              .|.|:.....:..:.  ||..:...:||:.|..:.||.|..:|
  Rat   432 LSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSI 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	116/466 (25%)
		Neur_chan_LBD	52..247	CDD:280998	59/213 (28%)
		Neur_chan_memb	255..434	CDD:280999	49/228 (21%)
Htr3a	XP_006243083.1	LIC	5..482	CDD:273305	119/495 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810