Protein Alignment nAChRbeta3 and chrna2a

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_001035417.1
• Gene: chrna2a / 678575
• ZFINID: ZDB-GENE-040108-2
• Length: 520
• Species: Danio rerio
• Alignment Length: 408
• Identity: 111/408 - (27%)
• Similarity: 193/408 - (47%)
• Gaps: 54/408 - (13%)

  Fly    50 ALDRLHAGLFTNYDSDVQPVFQGTPTNVSLEMVVTY-------IDIDELNGKLTTHCWLNLRWRD 107
            |.|:|...||..|:...:||     .|:|..::|.:       ||:||.|..:||:.||...|.|
Zfish    36 AEDKLFHKLFIGYNKWSRPV-----RNISDVVIVKFGLSIAQLIDVDEKNQMMTTNVWLKQEWND 95

  Fly   108 EERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGGLMAETQVT---LSHDGHFRWMPPAVYTA 169
            .:..|.||::||:|.|.:.|..:|.|.|.|:|..:|. .|.|.:|   |.|.|...|:|||:|.:
Zfish    96 YKLRWNPSEFDNVTSIRVPSEMIWVPDIVLYNNADGE-FAVTHMTKAHLFHTGKVSWVPPAIYKS 159

  Fly   170 YCELNMLNWPHDKQSCKLKIGSW---GLKVVLPE-NGTARGESLDHDDLVQSPEWEIVDSRAHFV 230
            .|.:::..:|.|:|:||:|.|||   ..|:.|.: .||     :|..|..:|.||.|:::...:.
Zfish   160 SCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQIEGT-----VDLKDYWESGEWAIINAVGTYN 219

  Fly   231 SQDY------YGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLII 289
            ::.|      |..:.|....:|....||..:..|...|..|.:..|:||... ||||.:...:::
Zfish   220 TKKYDCCHEIYPDITYFFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDC-GEKITLCISVLL 283

  Fly   290 VIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYLATGKHKR-----RLPEAL 349
            .:..||:...:::|..|...||:..:...:::::::|.::.|.||.:    |.|     .:|..:
Zfish   284 SLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNV----HHRSPSTHSMPRWV 344

  Fly   350 RKLLHGHLGTWLLLSVFSTTGESQAEKTKEMDEHPYEEADEQESSPLGINHTEVPGAKANQFDWA 414
            ..:...|:..||.:            :..|.::.|.:.|:...|.......|.|.|......::.
Zfish   345 HSVFLDHIPRWLFM------------RRPEPEKKPKKTANLSTSKSWFQQETGVDGLVCQDMEFG 397

  Fly   415 L-LATAVDRISFVSFSLA 431
            : |:|::...|..|..|:
Zfish   398 IGLSTSISSPSATSLHLS 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	111/408 (27%)
		Neur_chan_LBD	52..247	CDD:280998	69/214 (32%)
		Neur_chan_memb	255..434	CDD:280999	38/183 (21%)
chrna2a	NP_001035417.1	LIC	9..513	CDD:273305	111/408 (27%)
		Neur_chan_LBD	37..243	CDD:280998	70/216 (32%)
		Neur_chan_memb	250..511	CDD:280999	38/183 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810