Protein Alignment nAChRbeta3 and Chrna10

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: XP_006229953.1
• Gene: Chrna10 / 64574
• RGDID: 620142
• Length: 492
• Species: Rattus norvegicus
• Alignment Length: 422
• Identity: 118/422 - (27%)
• Similarity: 191/422 - (45%)
• Gaps: 50/422 - (11%)

  Fly    53 RLHAGLFTNYDSDVQPVFQGTPT-NVSLEMVVT-YIDIDELNGKLTTHCWLNLRWRDEERVWQPS 115
            :|...||.||.|.::||.....| ||:||:.:: .||:||.|..||.:.|:...|.|....|.|.
  Rat    77 KLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLHWDPK 141

  Fly   116 QYDNITQITLKSSEVWTPQITLFN--GDEGGLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNW 178
            .|.::..|.:.|..||.|.|.|:|  ..:....|.|.|.:.|||..||..||:..:.|.:::..:
  Rat   142 AYGDLDAIRIPSRLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRWDAPAITRSSCRVDVSAF 206

  Fly   179 PHDKQSCKLKIGSW---GLKV-VLPENGTARGESLDHDDLVQSPEWEIVDSRA------HFVSQD 233
            |.|.|.|.|..|||   |.:: |.|     ||.|....|.|::.||.::...|      :....:
  Rat   207 PFDAQRCGLTFGSWTHGGHQLDVRP-----RGTSASLADFVENVEWRVLGMPARRRVLTYGCCSE 266

  Fly   234 YYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYF 298
            .|..:.:||..:||::.|...:..|...|.:||..||.||.. .|||:.:...:::.:..|.:..
  Rat   267 PYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPAD-SGEKVSLGVTVLLALTVFQLIL 330

  Fly   299 AQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYL-ATGKHKRRLPEALRKLLHGHLGTWLL 362
            |:.:|. :.:.||:..:|..::..::.||.:.:|::.| ..|.:...:|...|.||.|||...|.
  Rat   331 AESMPP-AESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPVPAWARVLLLGHLAKGLC 394

  Fly   363 LSVFSTTGESQAEKTKEMDEHPYEEADEQESSPLG-------INHTEV---------------PG 405
            :   ...|| ...::|.::..|  ......:||.|       :.|.|.               ..
  Rat   395 V---RERGE-PCGQSKPLESAP--SLQPPPASPAGPCHEPRCLCHQEALLHHIASIASTFRSHRA 453

  Fly   406 AKANQFDWALLATAVDRISFVSFSLAFLILAI 437
            |:....||..||..:||.....|....|::::
  Rat   454 AQRRHEDWKRLARVMDRFFLGIFFCMALVMSL 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	118/420 (28%)
		Neur_chan_LBD	52..247	CDD:280998	67/207 (32%)
		Neur_chan_memb	255..434	CDD:280999	47/201 (23%)
Chrna10	XP_006229953.1	LIC	60..476	CDD:273305	116/411 (28%)
		Neur_chan_LBD	77..280	CDD:280998	67/207 (32%)
		Neur_chan_memb	288..482	CDD:280999	47/201 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48230
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820