DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta3 and chrna9a

DIOPT Version :10

Sequence 1:NP_525098.1 Gene:nAChRbeta3 / 33228 FlyBaseID:FBgn0031261 Length:441 Species:Drosophila melanogaster
Sequence 2:XP_021326868.1 Gene:chrna9a / 568807 ZFINID:ZDB-GENE-090312-63 Length:580 Species:Danio rerio


Alignment Length:391 Identity:106/391 - (27%)
Similarity:178/391 - (45%) Gaps:46/391 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 LLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGT--PTNVSLE 80
            :.|.:.:.:||..:.|..|..|.        |.|:.|..|    |.:.::|| :.|  ..||:|:
Zfish     4 IFLVIHISLLLHAVFSAQGRFAQ--------KLLNDLMEG----YSNALRPV-EDTDKALNVTLQ 55

  Fly    81 MVVTYI-DIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNG---- 140
            :.::.| |:||.|..|||:.|:...|.|....|...:||.:..|.:.|:.||.|.|.|:|.    
Zfish    56 ITLSQIKDMDERNQVLTTYLWVRQIWHDAYLSWDKEEYDGLEVIRIPSNLVWRPDIVLYNNADEE 120

  Fly   141 DEGGLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGT-- 203
            |..| ..:|.|.|.::|...|..||:..:.|::::..:|.|.|.|.|..|||      ..||.  
Zfish   121 DSSG-PPDTNVVLRYNGEITWDSPAITKSSCKVDVSYFPFDSQECNLTFGSW------TYNGNQV 178

  Fly   204 --ARG-ESLDHDDLVQSPEWE------IVDSRAHFVSQDYYGYMEYTLTAQRRSSMYTAVIYTPA 259
              |.| ||.|..|.|.:.|||      :.:...:....|.|..:.||:..:||||.|...:..|.
Zfish   179 DIAMGMESGDLSDFVDNVEWECHGMPAVKNVIMYGCCSDPYPDITYTVLLKRRSSFYIFNLLLPC 243

  Fly   260 SCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLS 324
            ..|..||...|:||.. .|||:.:...:::.:..|.:..|:.:|. |.:.||:..:|..::..::
Zfish   244 FLISFLAPLGFYLPAD-SGEKVSLGVTVLLALTVFQLMVAESMPP-SESVPLIGKYYIATMTMIT 306

  Fly   325 VSTIVEVLVLYL-ATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEMDEHPYEEA 388
            .||.:.:.::.: ..|...:.:|...:.|:..::.     .:|......:...|.|.|..|:...
Zfish   307 ASTSLTIFIMNIHFCGAEAKPVPHWAKVLIIDYMS-----KIFFVYEVGENCTTPESDRGPFFSE 366

  Fly   389 D 389
            |
Zfish   367 D 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta3NP_525098.1 LIC 39..437 CDD:455710 101/370 (27%)
chrna9aXP_021326868.1 LGIC_ECD_nAChR_A9 25..232 CDD:349823 69/226 (31%)
Cys-loop 150..164 CDD:349823 4/13 (31%)
LGIC_TM_cation 233..>320 CDD:349853 21/88 (24%)
TM1 helix 233..257 CDD:349853 7/23 (30%)
TM2 helix 265..286 CDD:349853 2/20 (10%)
TM3 helix 296..318 CDD:349853 3/21 (14%)

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