Protein Alignment nAChRbeta3 and chrna9a

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: XP_021326868.1
• Gene: chrna9a / 568807
• ZFINID: ZDB-GENE-090312-63
• Length: 580
• Species: Danio rerio
• Alignment Length: 391
• Identity: 106/391 - (27%)
• Similarity: 178/391 - (45%)
• Gaps: 46/391 - (11%)

  Fly    18 LLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGT--PTNVSLE 80
            :.|.:.:.:||..:.|..|..|.        |.|:.|..|    |.:.::|| :.|  ..||:|:
Zfish     4 IFLVIHISLLLHAVFSAQGRFAQ--------KLLNDLMEG----YSNALRPV-EDTDKALNVTLQ 55

  Fly    81 MVVTYI-DIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNG---- 140
            :.::.| |:||.|..|||:.|:...|.|....|...:||.:..|.:.|:.||.|.|.|:|.
Zfish    56 ITLSQIKDMDERNQVLTTYLWVRQIWHDAYLSWDKEEYDGLEVIRIPSNLVWRPDIVLYNNADEE 120

  Fly   141 DEGGLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGT-- 203
            |..| ..:|.|.|.::|...|..||:..:.|::::..:|.|.|.|.|..|||      ..||.
Zfish   121 DSSG-PPDTNVVLRYNGEITWDSPAITKSSCKVDVSYFPFDSQECNLTFGSW------TYNGNQV 178

  Fly   204 --ARG-ESLDHDDLVQSPEWE------IVDSRAHFVSQDYYGYMEYTLTAQRRSSMYTAVIYTPA 259
              |.| ||.|..|.|.:.|||      :.:...:....|.|..:.||:..:||||.|...:..|.
Zfish   179 DIAMGMESGDLSDFVDNVEWECHGMPAVKNVIMYGCCSDPYPDITYTVLLKRRSSFYIFNLLLPC 243

  Fly   260 SCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLS 324
            ..|..||...|:||.. .|||:.:...:::.:..|.:..|:.:|. |.:.||:..:|..::..::
Zfish   244 FLISFLAPLGFYLPAD-SGEKVSLGVTVLLALTVFQLMVAESMPP-SESVPLIGKYYIATMTMIT 306

  Fly   325 VSTIVEVLVLYL-ATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEMDEHPYEEA 388
            .||.:.:.::.: ..|...:.:|...:.|:..::.     .:|......:...|.|.|..|:...
Zfish   307 ASTSLTIFIMNIHFCGAEAKPVPHWAKVLIIDYMS-----KIFFVYEVGENCTTPESDRGPFFSE 366

  Fly   389 D 389
            |
Zfish   367 D 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	101/370 (27%)
		Neur_chan_LBD	52..247	CDD:280998	65/212 (31%)
		Neur_chan_memb	255..434	CDD:280999	28/136 (21%)
chrna9a	XP_021326868.1	Neur_chan_LBD	25..231	CDD:308532	68/225 (30%)
		Neur_chan_memb	239..>367	CDD:308533	27/134 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48230
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920