Protein Alignment nAChRbeta3 and chrna6

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_001036149.1
• Gene: chrna6 / 555747
• ZFINID: ZDB-GENE-090312-91
• Length: 512
• Species: Danio rerio
• Alignment Length: 488
• Identity: 121/488 - (24%)
• Similarity: 203/488 - (41%)
• Gaps: 115/488 - (23%)

  Fly    49 KALDRLHAGLFTNYDSDVQPVFQ-GTPTNVSLEMVVT-YIDIDELNGKLTTHCWLNLRWRDEERV 111
            |..|||...||..|:..::||.. ..|..|..|:.:: .:.:||:|..:.|:.||...|.|.:..
Zfish    25 KGEDRLFRRLFRRYNQFIRPVENVSDPVTVEFEVSISQLVKVDEVNQIMETNLWLRHIWNDYKLK 89

  Fly   112 WQPSQYDNITQITLKSSEVWTPQITLFNGDEGGLMAE--TQVTLSHDGHFRWMPPAVYTAYCELN 174
            |.|:::|.|..|.:.|:::|.|.|.|:|...|..:.|  |:..|..||...|:|||::.:.|.::
Zfish    90 WSPAEFDGIEFIRVPSNKIWRPDIVLYNNAVGDFLVEDKTKALLKFDGTITWVPPAIFKSSCPMD 154

  Fly   175 MLNWPHDKQSCKLKIGSW-----GLKVVLPENGTARGESLDHDDLVQSPEWEIVDSRA--HFVS- 231
            :..:|.|.|:|.:|.|||     .:.:||      .|..::..|..:|.||||:|:..  |.:.
Zfish   155 ITYFPFDYQNCSMKFGSWTYDKAKIDLVL------IGSKVNLKDFWESGEWEIIDAPGYKHDIKY 213

  Fly   232 ---QDYYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAA 293
               ::.|..:.|:...:|....||..:..|...|..|.:..|:||... |||:.:...:::.:..
Zfish   214 NCCEEIYPDITYSFYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDC-GEKVTLCISVLLSLTV 277

  Fly   294 FLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVL---YLATGKHK----------RRL 345
            ||:...:.:|..|...||:..:...:::::::|.::.|.||   |.....|.          |.|
Zfish   278 FLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMTHTMPSWVHTVFLRAL 342

  Fly   346 PE--ALRKLLH-------------GHLGTWLLLSVFSTTGESQAEKTK----------EMDE--- 382
            |.  .:|:.|.             |..||..     ...||.:..|..          |..|
Zfish   343 PRIMLMRRPLDLSESSGKGGLETGGSSGTGA-----GRGGEGKKRKNSGSQQGAMNSLEFGEGKA 402

  Fly   383 -----------HPYEEADE-------QESSPLGIN--------HTEVPGA--------------- 406
                       ||.:||.|       ::.||..||        ..|:..|
Zfish   403 ALEGKKGGCPCHPLKEATEGDCGKVSRQLSPQAINTVVAFSVVSPEIKQAIESVKYIAENMRSRN 467

  Fly   407 KANQF--DWALLATAVDRISFVSFSLAFLILAI 437
            ||.:.  ||..:|..:|||    |...|:::.:
Zfish   468 KAKEVEDDWKYVAMVIDRI----FLWVFVLVCV 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	121/486 (25%)
		Neur_chan_LBD	52..247	CDD:280998	62/209 (30%)
		Neur_chan_memb	255..434	CDD:280999	55/262 (21%)
chrna6	NP_001036149.1	LIC	38..504	CDD:273305	115/475 (24%)
		Neur_chan_LBD	38..233	CDD:280998	58/200 (29%)
		Neur_chan_memb	240..503	CDD:280999	55/267 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910