DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta3 and Chrnd

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_062171.1	Gene:	Chrnd / 54240	RGDID:	2352	Length:	517	Species:	Rattus norvegicus

Alignment Length:	422	Identity:	109/422 - (25%)
Similarity:	184/422 - (43%)	Gaps:	51/422 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 RLHAGLF--TNYDSDVQPVFQGTP-TNVSLEMVVT-YIDIDELNGKLTTHCWLNLRWRDEERVWQ 113
            ||...||  ..|:.:::||.:... .:|:|.:.:: .|.:.|:...|||:.|::..|.|....|.
  Rat    27 RLIQHLFEEKGYNKELRPVARKEDIVDVALSLTLSNLISLKEVEETLTTNVWIDHAWIDSRLQWN 91

  Fly   114 PSQYDNITQITLKSSEVWTPQITLFNGDEGGLMAE--TQVTLSHDGHFRWMPPAVYTAYCELNML 176
            .:::.|||.:.|.|..||.|:|.|.|.::|.....  ..|.:|..||..|:|||::.:.|.:::.
  Rat    92 ANEFGNITVLRLPSDMVWLPEIVLENNNDGSFQISYACNVLVSDSGHVTWLPPAIFRSSCPISVT 156

  Fly   177 NWPHDKQSCKLKIGSWGLKVVLPENGTARGES-------------LDHDDLVQSPEWEIVDSRAH 228
            .:|.|.|:|.||..|  ||....|...:..:.             :|.:...::.|||||...|.
  Rat   157 YFPFDWQNCSLKFSS--LKYTAKEIRLSLKQEEEDNRSYPIEWIIIDPEGFTENGEWEIVHRAAK 219

  Fly   229 F-----VSQDYYGYMEYT--LTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGL 286
            .     |..|...:.:.|  |..:|:...|...|..|...|..:....|:||... |||..:...
  Rat   220 VNVDPSVPMDSTNHQDVTFYLIIRRKPLFYIINILVPCVLISFMINLVFYLPGDC-GEKTSVAIS 283

  Fly   287 LIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVL---YLATGKH------K 342
            :::..:.||:..::.||..|...|||..|....::.:::..::.|:||   :.....|      |
  Rat   284 VLLAQSVFLLLISKRLPATSMAIPLVGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVK 348

  Fly   343 RRLPEALRKLLH------GHLGTWLLLSVFSTTGE-SQAEK---TKEMDEHPYEEADEQESSPLG 397
            :...|.|.||||      ...|...|:...|:.|. |:||:   .|...:..:|:..|:......
  Rat   349 KFFLETLPKLLHMSRPEEEDPGPRALIRRTSSLGYISKAEEYFSLKSRSDLMFEKQSERHGLARR 413

  Fly   398 INHTEVPGAKANQFDWAL---LATAVDRISFV 426
            :.....|.|.:.|....|   :..|||..:|:
  Rat   414 LTTARKPPASSEQVQQELFNEMKPAVDGANFI 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	109/422 (26%)
		Neur_chan_LBD	52..247	CDD:280998	60/219 (27%)
		Neur_chan_memb	255..434	CDD:280999	47/194 (24%)
Chrnd	NP_062171.1	LIC	23..476	CDD:273305	109/422 (26%)
		Neur_chan_LBD	25..246	CDD:280998	61/220 (28%)
		Neur_chan_memb	253..489	CDD:280999	47/194 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810