Protein Alignment nAChRbeta3 and Chrnb2

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_062170.1
• Gene: Chrnb2 / 54239
• RGDID: 2350
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 463
• Identity: 105/463 - (22%)
• Similarity: 190/463 - (41%)
• Gaps: 117/463 - (25%)

  Fly    60 TNYDSDVQPVFQGTPTNVSLEMVVT---YIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNIT 121
            :.|:..::|...|:.. |:::::|:   .|.:.|....:||:.||...|.|....|:|..:||:.
  Rat    39 SRYNKLIRPATNGSEL-VTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMK 102

  Fly   122 QITLKSSEVWTPQITLFNGDEGGLMAE----TQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDK 182
            ::.|.|..:|.|.:.|:|..:|  |.|    :...:|:||...|:|||:|.:.|::.:.::|.|:
  Rat   103 KVRLPSKHIWLPDVVLYNNADG--MYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQ 165

  Fly   183 QSCKLKIGSW-----GLKVVLPENGTARGESLDHDDLVQSPEWEIV---DSRAHFVSQDYYGYME 239
            |:|.:|..||     .:.:||      :.:....||...|.||:|:   ..|........|..:.
  Rat   166 QNCTMKFRSWTYDRTEIDLVL------KSDVASLDDFTPSGEWDIIALPGRRNENPDDSTYVDIT 224

  Fly   240 YTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPV 304
            |....:|:...||..:..|...|..||:..|:||... |||:.:...:::.:..||:..::::|.
  Rat   225 YDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDC-GEKMTLCISVLLALTVFLLLISKIVPP 288

  Fly   305 LSNNTPLV--VIFYSTSLLYLSVSTIVEVL--------------------------VLYLATGKH 341
            .|.:.|||  .:.::..|:..|:.|.|.||                          :|:|...:|
  Rat   289 TSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRH 353

  Fly   342 ---KRRLPEALRKLLHGHLGTWLLL-----------------SVFSTTGESQAEKT--------- 377
               ::||  .||:......|...|.                 ||....|..:||.|
  Rat   354 RCARQRL--RLRRRQREREGAGALFFREGPAADPCTCFVNPASVQGLAGAFRAEPTAAGPGRSVG 416

  Fly   378 -------------KEMDEHPYEEADEQESSPLGINHTEVPGAKANQFDWALLATAVDRISFVSFS 429
                         :.:.:|...|.|:|                :.:.||..:|..:||:    |.
  Rat   417 PCSCGLREAVDGVRFIADHMRSEDDDQ----------------SVREDWKYVAMVIDRL----FL 461

  Fly   430 LAFLILAI 437
            ..|:.:.:
  Rat   462 WIFVFVCV 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	105/461 (23%)
		Neur_chan_LBD	52..247	CDD:280998	53/201 (26%)
		Neur_chan_memb	255..434	CDD:280999	49/248 (20%)
Chrnb2	NP_062170.1	LIC	28..477	CDD:273305	105/463 (23%)
		Neur_chan_LBD	28..233	CDD:280998	54/202 (27%)
		Neur_chan_memb	240..476	CDD:280999	49/253 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810