DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta3 and Chrna10

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001074893.1	Gene:	Chrna10 / 504186	MGIID:	3609260	Length:	447	Species:	Mus musculus

Alignment Length:	462	Identity:	127/462 - (27%)
Similarity:	203/462 - (43%)	Gaps:	67/462 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GPGLPLLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPT-N 76
            |||..|||            .:|.....|:.:.|:     :|...||.||.|.::||.....| |
Mouse     9 GPGFLLLL------------FLPAECLGAEGRLAH-----KLFRDLFANYTSALRPVADTDQTLN 56

  Fly    77 VSLEMVVT-YIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFN- 139
            |:||:.:: .||:||.|..||.:.|:...|.|....|.|..|.::..|.:.||.||.|.|.|:|
Mouse    57 VTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLHWDPKAYGDLDAIRIPSSLVWRPDIVLYNK 121

  Fly   140 -GDEGGLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKV-VLP 199
             ..:....|.|.|.:.|||..||..||:..:.|.:::..:|.|.|.|.|..|||   |.:: |.|
Mouse   122 ADTQPPASASTNVVVRHDGAVRWDAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLDVRP 186

  Fly   200 ENGTARGESLDHDDLVQSPEWEIVDSRA------HFVSQDYYGYMEYTLTAQRRSSMYTAVIYTP 258
                 ||.|....|.|::.||.::...|      :....:.|..:.:||..:||::.|...:..|
Mouse   187 -----RGTSASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLP 246

  Fly   259 ASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYL 323
            ...|.:||..||.||.. .|||:.:...:::.:..|.:..|:.:|. :.:.||:..:|..::..:
Mouse   247 CVFISLLAPLAFHLPAD-SGEKVSLGVTVLLALTVFQLILAESMPP-AESVPLIGKYYMATMTMV 309

  Fly   324 SVSTIVEVLVLYL-ATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEMDEHPYEE 387
            :.||.:.:|::.| ..|.:...:|...|.||.|||...|.:   ...|| ...::|.::..|  .
Mouse   310 TFSTALTILIMNLHYCGPNAHPVPAWARVLLLGHLAKGLCV---RERGE-PCGQSKPLESAP--S 368

  Fly   388 ADEQESSPLGINH---------------TEVPG-------AKANQFDWALLATAVDRISFVSFSL 430
            .......|.|..|               ..:.|       |:....||..||..:||.....|..
Mouse   369 LQPPAGPPAGPCHEPRCLCHQEALLHHVASIAGTFRSHRAAQRRHEDWKRLARVMDRFFLGIFFC 433

  Fly   431 AFLILAI 437
            ..|::::
Mouse   434 MALVMSL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	120/434 (28%)
		Neur_chan_LBD	52..247	CDD:280998	68/208 (33%)
		Neur_chan_memb	255..434	CDD:280999	46/201 (23%)
Chrna10	NP_001074893.1	LGIC_ECD	30..236	CDD:355788	70/215 (33%)
		LGIC_TM_cation	239..>324	CDD:349853	22/86 (26%)
		TM1 helix	239..261	CDD:349853	7/21 (33%)
		Neur_chan_memb	243..437	CDD:367256	46/201 (23%)
		TM2 helix	269..290	CDD:349853	2/20 (10%)
		TM3 helix	300..322	CDD:349853	4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48230
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820