Protein Alignment nAChRbeta3 and nAChRbeta2

DIOPT Version :10

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Alignment Length: 484
• Identity: 125/484 - (25%)
• Similarity: 216/484 - (44%)
• Gaps: 79/484 - (16%)

  Fly    27 LLMGLTSVPGATATAD---PKNANVKALDRLHAGLFTNYDSDVQPVFQGTPT-NVSLEMVVT-YI 86
            ||.....||.|.:||.   ..|.:.|   ||:..|.:||:..::||...|.| .|.|.:.:: .|
  Fly     6 LLCVFLLVPLANSTAPISFEANPDTK---RLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLI 67

  Fly    87 DIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGG----LMA 147
            :::..|..:||:.|:..||.|.:..|.|.:|..:.|:.:.|..:|.|.|.|:|..:|.    ||
  Fly    68 EVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLM- 131

  Fly   148 ETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPENGTARGESL 209
             |:.||.:.|...|.|||:|.:.||:|:..:|:|:|.|.:|.|||   |.:|.|.......|.:|
  Fly   132 -TKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNL 195

  Fly   210 -----DHDDLVQSPEWEIVDSRAHFVSQDYY-------GYMEYTLTAQRRSSMYTAVIYTPASCI 262
                 |..:...|.||:|::..| ..:::||       ..:.:.||.:|::..||..:..|...:
  Fly   196 VQVGIDLTEFYLSVEWDILEVPA-TKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVAL 259

  Fly   263 VILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLV--VIFYSTSLLYLSV 325
            ..|.:..|:||.. .|||:.:...:::.:..|.:..|:::|..|...||:  .:.::..|:.|||
  Fly   260 TFLTVLVFYLPSD-SGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSV 323

  Fly   326 STIVEVLVLYLATGKHKRRLPEALRKLLHGHLGTWLLL------------SVFSTTGESQAEKTK 378
            .|.|.||.::..:.......| .:|||....:...:::            |..|....::.:...
  Fly   324 WTTVCVLNIHFRSPSTHNMSP-LVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRD 387

  Fly   379 EMDEHPYEEADEQESS---------------PLGINHTEVPGAKANQF----------------D 412
            .:.:.|.|..|.|:.:               |..:....:...:|.:|                |
  Fly   388 SISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVED 452

  Fly   413 WALLATAVDRISFVSFSLA--FLILAIRC 439
            |..::..:||.....|:|:  |..|||.|
  Fly   453 WKFVSMVLDRFFLWLFTLSCVFGTLAIIC 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:455710	117/468 (25%)
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	120/477 (25%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	69/223 (31%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)