DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta3 and nAChRbeta2

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	484	Identity:	125/484 - (25%)
Similarity:	216/484 - (44%)	Gaps:	79/484 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LLMGLTSVPGATATAD---PKNANVKALDRLHAGLFTNYDSDVQPVFQGTPT-NVSLEMVVT-YI 86
            ||.....||.|.:||.   ..|.:.|   ||:..|.:||:..::||...|.| .|.|.:.:: .|
  Fly     6 LLCVFLLVPLANSTAPISFEANPDTK---RLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLI 67

  Fly    87 DIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGG----LMA 147
            :::..|..:||:.|:..||.|.:..|.|.:|..:.|:.:.|..:|.|.|.|:|..:|.    ||
  Fly    68 EVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLM- 131

  Fly   148 ETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPENGTARGESL 209
             |:.||.:.|...|.|||:|.:.||:|:..:|:|:|.|.:|.|||   |.:|.|.......|.:|
  Fly   132 -TKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNL 195

  Fly   210 -----DHDDLVQSPEWEIVDSRAHFVSQDYY-------GYMEYTLTAQRRSSMYTAVIYTPASCI 262
                 |..:...|.||:|::..| ..:::||       ..:.:.||.:|::..||..:..|...:
  Fly   196 VQVGIDLTEFYLSVEWDILEVPA-TKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVAL 259

  Fly   263 VILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLV--VIFYSTSLLYLSV 325
            ..|.:..|:||.. .|||:.:...:::.:..|.:..|:::|..|...||:  .:.::..|:.|||
  Fly   260 TFLTVLVFYLPSD-SGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSV 323

  Fly   326 STIVEVLVLYLATGKHKRRLPEALRKLLHGHLGTWLLL------------SVFSTTGESQAEKTK 378
            .|.|.||.::..:.......| .:|||....:...:::            |..|....::.:...
  Fly   324 WTTVCVLNIHFRSPSTHNMSP-LVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRD 387

  Fly   379 EMDEHPYEEADEQESS---------------PLGINHTEVPGAKANQF----------------D 412
            .:.:.|.|..|.|:.:               |..:....:...:|.:|                |
  Fly   388 SISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVED 452

  Fly   413 WALLATAVDRISFVSFSLA--FLILAIRC 439
            |..::..:||.....|:|:  |..|||.|
  Fly   453 WKFVSMVLDRFFLWLFTLSCVFGTLAIIC 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	117/468 (25%)
		Neur_chan_LBD	52..247	CDD:280998	67/215 (31%)
		Neur_chan_memb	255..434	CDD:280999	42/225 (19%)
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	120/477 (25%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	69/223 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840