DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta3 and nAChRalpha2

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	122/543 - (22%)
Similarity:	219/543 - (40%)	Gaps:	154/543 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PLLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNVSLEM 81
            ||.|.:::.:|...:.:.|.|              .||:..|.:||:..::||...|.| |.:::
  Fly    25 PLCLLLVLLLLCETVQANPDA--------------KRLYDDLLSNYNRLIRPVSNNTDT-VLVKL 74

  Fly    82 VVTYIDIDELNGK---LTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEG 143
            .:....:.:||.|   |||:.||...|:|.:..|.||:|..:|::.:.|..:|.|.|.|:|..:|
  Fly    75 GLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADG 139

  Fly   144 GLMAE--TQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW-------GLKVVLP 199
            ..:..  |:..|.:.|...|.|||::.:.||:::..:|.|:|:|.:|.|||       .||.:..
  Fly   140 EYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQ 204

  Fly   200 ENGTARGESLDHDDLVQ----------SPEWEI--VDSRAHFVSQDYY-----GYME--YTLTAQ 245
            :|        |.|:.|:          |.||:|  |.:..|   :.||     .|.:  :.:|.:
  Fly   205 KN--------DKDNKVEIGIDLREYYPSVEWDILGVPAERH---EKYYPCCAEPYPDIFFNITLR 258

  Fly   246 RRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTP 310
            |::..||..:..|...|..|::..|:||.. .||||.:...:::....|.:..::::|..|...|
  Fly   259 RKTLFYTVNLIIPCVGISYLSVLVFYLPAD-SGEKIALCISILLSQTMFFLLISEIIPSTSLALP 322

  Fly   311 LVVIFYSTSLLYLSVSTIVEVLVL---YLATGKHKRR---------------------------- 344
            |:..:...::|.:.:|.::.:::|   |.....||.|
  Fly   323 LLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLA 387

  Fly   345 ------------------------------LPEALRKL-----------------------LHGH 356
                                          .|::||::                       |.|.
  Fly   388 ANKINYGLKFSKTKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGA 452

  Fly   357 LGTWL--------LLSVFSTTGESQAEKTKEMDEHPYEEADEQESSPLGINH--TEVPGAKANQF 411
            ||..|        |.||.|...:|.:: .....::|: |.::...:.:.|.|  .......|...
  Fly   453 LGGGLSTLSGYNGLPSVLSGLDDSLSD-VAARKKYPF-ELEKAIHNVMFIQHHMQRQDEFNAEDQ 515

  Fly   412 DWALLATAVDRISFVSFSLAFLI 434
            ||..:|..:||:....|.:|.|:
  Fly   516 DWGFVAMVMDRLFLWLFMIASLV 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	116/521 (22%)
		Neur_chan_LBD	52..247	CDD:280998	65/225 (29%)
		Neur_chan_memb	255..434	CDD:280999	47/272 (17%)
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	67/244 (27%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	116/507 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910