Protein Alignment nAChRbeta3 and SecCl

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 388
• Identity: 86/388 - (22%)
• Similarity: 136/388 - (35%)
• Gaps: 101/388 - (26%)

  Fly    52 DRLHAGLFTNYDSDVQPVFQGTPTNVSLEMVVTYIDIDELNGKL---TTHCWLNLRWRDEERVWQ 113
            |||....  .||||.:.:    |..|...:.|.:  :..||..|   ..|..|.||::|:...::
  Fly    58 DRLERPF--EYDSDGKRL----PIVVKTRIYVYF--LQNLNSDLLQFKMHALLQLRFQDKRLAYK 114

  Fly   114 P-SQYDNITQITLKSSEVWTPQITLFNGDEGGLMA----ETQVTLSHDGHFRWMPPAVYTAYCEL 173
            . ::.|||......|..:|.|.|...|..|..::.    :...:||.:|:.........:.||.:
  Fly   115 AFNRSDNILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWM 179

  Fly   174 NMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGESLDHDDLVQSPEWE----------------- 221
            |...:|.|:|.|...:.||               ..:..||:.  |||
  Fly   180 NFQKFPFDQQFCSTVLESW---------------MYNTSDLIL--EWEPHTPISFDPEMRLTEYN 227

  Fly   222 ---------IV----DSRAHFVSQDYYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLP 273
                     ||    |:..|......|..:.:|:..:|....|....|.|:..||.::..:|||.
  Fly   228 MAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQ 292

  Fly   274 PHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLV-------------VIFYSTSLL-YLS 324
            ......:||:.       .:.::.|..|....|.|.|.|             ..|...||: :..
  Fly   293 ADASPPRIMLG-------TSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAF 350

  Fly   325 VSTI---VEVLVLYLATGKH--KRRL-PEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEMD 381
            |:||   .|.:.|.....|:  |..| |...|:.:.|           |.:.||:|.....:|
  Fly   351 VNTIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGG-----------SLSNESRARSCSSLD 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	86/388 (22%)
		Neur_chan_LBD	52..247	CDD:280998	50/232 (22%)
		Neur_chan_memb	255..434	CDD:280999	34/147 (23%)
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	86/388 (22%)
		Neur_chan_LBD	44..267	CDD:280998	51/233 (22%)
		Neur_chan_memb	275..503	CDD:280999	34/146 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447271
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940