Protein Alignment nAChRbeta3 and lgc-29

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_001317792.1
• Gene: lgc-29 / 3896858
• WormBaseID: WBGene00044528
• Length: 398
• Species: Caenorhabditis elegans
• Alignment Length: 414
• Identity: 83/414 - (20%)
• Similarity: 153/414 - (36%)
• Gaps: 108/414 - (26%)

  Fly    23 LMGMLLMGLTSVPGATATADPKNANVKAL----DRLHAGLFTNYDSDVQPVF--------QGT-- 73
            |:..|::.|.|....:.|:: :.||.|..    |||...||.:||..:..::        .||
 Worm     7 LLFYLMVPLWSTDSQSMTSE-QMANYKRFLGHQDRLFEKLFKSYDPGINAIYTLHSVPETNGTVH 70

  Fly    74 ----PTNVSLEMVVTYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQ 134
                ...:.|.| :..:::.|...|.|........|.|....|.|..|..|..|.:..|:||.|:
 Worm    71 PPRFEITIQLSM-MKLVEVVEPEEKATFLFDYRADWYDTRLSWDPEDYGGINHIYVPRSKVWIPE 134

  Fly   135 ITLFNGDEGGLMAETQVTLSHDGHFRWMP---------PAVYTAYCELNMLNWPHDKQSCKLK-- 188
            .|:.:    ...:|.:|..:....:.|:.         .:|.:..|::::..:|.|..:|.:.
 Worm   135 TTIVD----CFSSEIKVFDNEYTRYAWLHSNGSIGMYIASVTSVVCQMDVYKFPMDTHTCSVNFL 195

  Fly   189 -----------IGSWGLKVVLPENGTARGESLDHDDLVQSPEWE----------IVDSRAHFVSQ 232
                       :|..|   .||......|..          ||:          :||:..:..
 Worm   196 FMTYQLEEFTIVGKTG---TLPRPVEQLGNG----------EWQMKSIQIAFEPVVDNLTYLT-- 245

  Fly   233 DYYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMY 297
                  ::..|..|....|..::..||..|.:|::.|.::..:...||..:....|:.::..|:.
 Worm   246 ------KFEATFSRNPGFYIVLVMIPAYFINVLSIVALFMDINNRSEKFTVGMTNIMSMSFILVI 304

  Fly   298 FAQLLPVLSNNTPLVVIFYSTSL--LYLSVSTIVEVLVLYLATGKHKRRLPEALRKLLHGHLGTW 360
            .|:.|| .:.|.|::.|:..|||  :..|::.:|                  ||.|
 Worm   305 LAEDLP-KTKNLPILAIYTVTSLAIMLCSLTAVV------------------ALPK--------- 341

  Fly   361 LLLSVFSTTGESQAEKTKEMDEHP 384
             |.:.::....::.||..:.||.|
 Worm   342 -LKAYYANRSLARGEKIPKNDEVP 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	79/398 (20%)
		Neur_chan_LBD	52..247	CDD:280998	44/240 (18%)
		Neur_chan_memb	255..434	CDD:280999	29/132 (22%)
lgc-29	NP_001317792.1	LIC	38..>337	CDD:273305	65/325 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48230
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820