Protein Alignment nAChRbeta3 and lgc-28

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_001022053.1
• Gene: lgc-28 / 3565225
• WormBaseID: WBGene00044301
• Length: 397
• Species: Caenorhabditis elegans
• Alignment Length: 352
• Identity: 71/352 - (20%)
• Similarity: 131/352 - (37%)
• Gaps: 60/352 - (17%)

  Fly    20 LQMLMGMLLMGLTSV-------PGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNV 77
            :.:..|:.|:.:.|:       ||      ......:|..:|...:...:| |..|:.:.....:
 Worm     1 MDLSTGVALLSMFSLNIQLEPSPG------EMEKRYEAETKLREDITKRFD-DTMPIKKDGYLQL 58

  Fly    78 SLEMVVTYI-DIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEV-----WTPQIT 136
            ...:.|.:| ||.:..|.|.........|.||..:|.||.|..|...:....|:     |||.:.
 Worm    59 IPLLHVDHIHDIQDEQGVLKMALTFTFTWMDERLMWNPSNYSGIRTFSTTRHEMWRKKFWTPTLM 123

  Fly   137 LFNGDEGGLMAET------QVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSC---------- 185
            :.:.......::.      .:.:|..|..|.....:.|..|.....::|:|.::|
 Worm   124 MTDVPNSRRPSDVFKPFDMDIYISSSGMVRTSARMMLTIPCRTGFGSYPNDYKNCTFTLMSPYYA 188

  Fly   186 -KLKIGSWG----LKVVLPENGTARGESLDHDDL-VQSPEW------EIVDSRAHFVSQDYYGYM 238
             :.:...||    .:.::....|   :.||...: :.:..:      |:||..:.|..:....:.
 Worm   189 DQFRFAQWGGAEFTRYLMSSRVT---DVLDFQLINIDTRNYYMFLGSEVVDDFSKFKPRHCRSFY 250

  Fly   239 EYTLTAQRRSSMYTAVIYTPASCI-VILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLL 302
            .|.|..:|.:...:..:..|.|.| |.||:|.|.  ||..|  ::..|..::....|.....|:|
 Worm   251 RYNLVLKRVNKFVSVQLIAPISVIAVFLAISGFL--PHFYG--LVCAGSALVYETIFTYDVEQVL 311

  Fly   303 PVLSNNTPLVVIFYSTSLLYLSVSTIV 329
            |...:..|::.|.    |.:|...|||
 Worm   312 PKDYSGMPMIAIL----LCFLFAETIV 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	66/326 (20%)
		Neur_chan_LBD	52..247	CDD:280998	41/228 (18%)
		Neur_chan_memb	255..434	CDD:280999	23/76 (30%)
lgc-28	NP_001022053.1	LGIC_ECD	62..>187	CDD:355788	26/124 (21%)
		LIC	67..>329	CDD:273305	56/272 (21%)
		Cys-loop	164..178	CDD:349787	3/13 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810