Protein Alignment nAChRbeta3 and ZACN

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_851321.2
• Gene: ZACN / 353174
• HGNCID: 29504
• Length: 412
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 98/455 - (21%)
• Similarity: 167/455 - (36%)
• Gaps: 116/455 - (25%)

  Fly    15 GLPLLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNVSL 79
            |..:.|.::.|....|       ||...|...||            |....||...| .|.|.|.
Human    14 GFSITLLLVHGQGFQG-------TAAIWPSLFNV------------NLSKKVQESIQ-IPNNGSA 58

  Fly    80 EMVV-------TYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITL 137
            .::|       ...::|.|...:::...|.|.|.|....|..|.:.. ..|||....:|||::|:
Human    59 PLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTPRLTI 122

  Fly   138 FNG------DEGGLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLK---IGSWG 193
            ...      |:     ..|..:..|||.:..........|...:|::|.|..:|.|.   :.:..
Human   123 LEALWVDWRDQ-----SPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYALSNTA 182

  Fly   194 LKV-----VLPENGTARGESLDHDDLVQSPEWEIVDSRAHFVSQDYYGYMEYTLTAQRRSSMYTA 253
            :::     |:.|..:.:.|.:.:|...|.|..::|..            .:.||..:..:.....
Human   183 MELEFQAHVVNEIVSVKREYVVYDLKTQVPPQQLVPC------------FQVTLRLKNTALKSII 235

  Fly   254 VIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMY---FAQLLPVLSNNTPLVVIF 315
            .:..||..: :||.....|.|....|:|   |..:.::.::|:.   ..|.||..|:..||::.:
Human   236 ALLVPAEAL-LLADVCGGLLPLRAIERI---GYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIYY 296

  Fly   316 YSTSLLYLSVSTIVEVLVLYLATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEM 380
            ::..||.|.:|||..||:..|               |..|:||        :.:|.|.|.:.::.
Human   297 FTILLLLLFLSTIETVLLAGL---------------LARGNLG--------AKSGPSPAPRGEQR 338

  Fly   381 DE-----HPYEEADEQESSPLGINHTEVPGAKANQFDWALLATAVDRISFVSFSLAFLILAIRCS 440
            :.     ||.||...              |.|.:|..|...|   |||.|:.:     ::.:.|:
Human   339 EHGNPGPHPAEEPSR--------------GVKGSQRSWPETA---DRIFFLVY-----VVGVLCT 381

  Fly   441  440
            Human   382  381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	92/426 (22%)
		Neur_chan_LBD	52..247	CDD:280998	43/215 (20%)
		Neur_chan_memb	255..434	CDD:280999	45/186 (24%)
ZACN	NP_851321.2	LIC	11..368	CDD:273305	93/435 (21%)
		Neur_chan_LBD	54..>187	CDD:280998	29/138 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	328..360		9/45 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810