DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta3 and nAChRalpha6

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	113/524 - (21%)
Similarity:	211/524 - (40%)	Gaps:	122/524 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PLLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVF-QGTPTNVSLE 80
            ||...:.:.:||:.|..:..:......|        ||...|.:.|::..:||. :..|..|...
  Fly     4 PLPASLSLFVLLIFLAIIKESCQGPHEK--------RLLNHLLSTYNTLERPVANESEPLEVKFG 60

  Fly    81 MVV-TYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGG 144
            :.: ..||:||.|..|||:.||||.|.|....|..::|..:..:.:..:::|.|.:.::|..:.|
  Fly    61 LTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEG 125

  Fly   145 L--MAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPENGTA 204
            .  ...|.:.:.|:|...::||.::.:.|::::..:|.|.|.|::|.|||   |.::.|..|...
  Fly   126 FDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSED 190

  Fly   205 RGESLDHDDLVQSPEWEIV------DSRAHFVSQDYYGYMEYTLTAQRRSSMYTAVIYTPASCIV 263
            .|   |..|.:.:.||.::      ::..:....:.|..:.:|:..:||:..|...:..|...|.
  Fly   191 GG---DLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLIS 252

  Fly   264 ILALSAFWLPPHMGGEKI-----------------------------MINGLLIIVIAAFLMYFA 299
            .:||..|.|||. .|||:                             :|...:::.:..||...|
  Fly   253 SMALLGFTLPPD-SGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVA 316

  Fly   300 QLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYLATGKHKR-----RLPEALRKLLHGHLGT 359
            :.||.:|:..||:..:::..:..::.|.::.|:||    ..|.|     .:|..::.:....| .
  Fly   317 ETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVL----NYHHRTADIHEMPPWIKSVFLQWL-P 376

  Fly   360 WLL----------------------LSVFSTTGESQAEKTKEMDE---HPYEEAD---------- 389
            |:|                      |.:...:.:|......::|:   |....:.
  Fly   377 WILRMGRPGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFG 441

  Fly   390 -----EQESSPLGINHTEVP-GAKANQF----------------DWALLATAVDRISFVSFSLAF 432
                 |:..:.:|.||.::. ..|..||                ||...|..|||...:.|:| |
  Fly   442 RPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTL-F 505

  Fly   433 LILA 436
            .|:|
  Fly   506 TIIA 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	108/502 (22%)
		Neur_chan_LBD	52..247	CDD:280998	52/207 (25%)
		Neur_chan_memb	255..434	CDD:280999	50/269 (19%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	111/517 (21%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	45/183 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447302
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940