Protein Alignment nAChRbeta3 and HTR3A

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_998786.3
• Gene: HTR3A / 3359
• HGNCID: 5297
• Length: 510
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 130/514 - (25%)
• Similarity: 213/514 - (41%)
• Gaps: 119/514 - (23%)

  Fly    21 QMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQ-GTPTNVSLEMVV- 83
            |.|:.:||..|.:...|..:   :|....||.||...|.|||...|:||.. ..||.||::::|
Human     7 QALLALLLPTLLAQGEARRS---RNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 68

  Fly    84 TYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNG--DEGGLM 146
            ..:::||.|..|||:.|....|.||...|.|..:||||::::.:..:|.|.| |.|.  |.|...
Human    69 AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDI-LINEFVDVGKSP 132

  Fly   147 AETQVTLSHDGHFR-WMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKVV---------LPEN 201
            ....|.:.|.|..: :.|..|.|| |.|::.|:|.|.|:|.|...|| |..:         |||.
Human   133 NIPYVYIRHQGEVQNYKPLQVVTA-CSLDIYNFPFDVQNCSLTFTSW-LHTIQDINISLWRLPEK 195

  Fly   202 GTARGESLDHDDLVQSPEWEIVDSRAHF-----VSQDYYGYMEYTLTAQRRSSMYTAVIYTPASC 261
            ..:     |....:...|||::....:|     .|.:||..|::.:..:||...|...:..|:..
Human   196 VKS-----DRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIF 255

  Fly   262 IVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLV-------------- 312
            ::::.:..|:|||: .||::.....|::..:.||:..:..||..:..|||:
Human   256 LMVMDIVGFYLPPN-SGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEK 319

  Fly   313 ------------------VIFYSTSLLYLSVSTIVEVLVLYLATGKHKRRL----PEALRKLLHG 355
                              .:::...:..|.:|....:.::.|.   ||:.|    |..||.|:..
Human   320 PAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLV---HKQDLQQPVPAWLRHLVLE 381

  Fly   356 HLGTWLLLSVFSTTGE-----SQAEKTKE---MDEH--------PYEEADEQESSPLGINHTEVP 404
            .: .|||.....:|.:     |||.||.:   |..|        .:|::.....||      ..|
Human   382 RI-AWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSP------PPP 439

  Fly   405 GAKAN--------------QF------------DWALLATAVDRISFVSFSLAFLILAI 437
            ..:|:              ||            ||..:.:.:|::.|..:.||.|..:|
Human   440 PREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSI 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	123/494 (25%)
		Neur_chan_LBD	52..247	CDD:280998	67/213 (31%)
		Neur_chan_memb	255..434	CDD:280999	49/256 (19%)
HTR3A	NP_998786.3	LIC	23..504	CDD:273305	125/498 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5722
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760