DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta3 and nAChRalpha7

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	118/526 - (22%)
Similarity:	209/526 - (39%)	Gaps:	138/526 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 MGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVF-QGTPTNVSLEM-VVTYI 86
            :|:|:|    :|...|....|..       ||| |..||:|..:||. :..|..:|..: ::..|
  Fly    46 LGLLIM----IPACAAGPHEKRL-------LHA-LLDNYNSLERPVVNESDPLQLSFGLTLMQII 98

  Fly    87 DIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFN-GDEG--GLMAE 148
            |:||.|..|.|:.||.|.|.|....|..|::..:..:.:....:|.|.:.::| .|||  |..|
  Fly    99 DVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYA- 162

  Fly   149 TQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPENGTARGESLD 210
            |.|.:.::|...::||.::.:.|::::..:|.|.|.|::|.|||   |.::.|.....|.|   |
  Fly   163 TNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGG---D 224

  Fly   211 HDDLVQSPEWEI--VDSRAHFVSQDYYG-----YMEYT--LTAQRRSSMYTAVIYTPASCIVILA 266
            ....:.:.||::  |..:.:.:   ||.     |::.|  :..:|::..|...:..|...|..:|
  Fly   225 ISSFITNGEWDLLGVPGKRNEI---YYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMA 286

  Fly   267 LSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEV 331
            |..|.|||. .|||:.:...:::.:..||...|:.:|..|:..||:..:::..:..::.|.:..:
  Fly   287 LLGFTLPPD-SGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTI 350

  Fly   332 LVLYLATGKHKRR-----------------LPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKE 379
            |:|    ..|.|.                 ||..||....|.:|........|::..:..||.::
  Fly   351 LIL----NYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQ 411

  Fly   380 -----------------------------------MDEHP------YEEADEQESSPLG------ 397
                                               :...|      |.:.|:....|:|
  Fly   412 IQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVV 476

  Fly   398 -------INHTEVPGAKANQF-------------------------DWALLATAVDRISFVSFSL 430
                   |:||.:..:...:.                         ||...|..|||:..:.|:|
  Fly   477 DGRLHEAISHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTL 541

  Fly   431 AFLILA 436
             |.|:|
  Fly   542 -FTIIA 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	114/511 (22%)
		Neur_chan_LBD	52..247	CDD:280998	59/211 (28%)
		Neur_chan_memb	255..434	CDD:280999	49/274 (18%)
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	113/509 (22%)
		Neur_chan_LBD	61..268	CDD:280998	61/221 (28%)
		Neur_chan_memb	275..552	CDD:280999	51/278 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940