Protein Alignment nAChRbeta3 and chrnb3b

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_775394.1
• Gene: chrnb3b / 317643
• ZFINID: ZDB-GENE-030102-4
• Length: 462
• Species: Danio rerio
• Alignment Length: 464
• Identity: 119/464 - (25%)
• Similarity: 204/464 - (43%)
• Gaps: 75/464 - (16%)

  Fly    24 MGMLLMGLTSVPGATATADPKNANVKALDR---LHAGLFTNYDSDVQPVFQGTPT-NVSLEMVVT 84
            |.:.::||.::..:.....|....|...:|   |...||..|...|:|:.....| .|...:.::
Zfish     1 MTLTVIGLFTLFTSIFATTPAREFVSLAEREDALLRDLFQGYQRWVRPILHANHTVKVRFGLKIS 65

  Fly    85 -YIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLF-NGD---EGG 144
             .:|:||.|..:||:.||...|.|.:..|.|..|..||.|.:.|..:|.|.|.|: |.|   ||.
Zfish    66 QLVDVDEKNQLMTTNVWLYEEWLDYKLRWNPENYGGITFIRVPSESIWLPDIVLYENADGRFEGS 130

  Fly   145 LMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWG-----LKVVLPENGTA 204
            :|  |:..:.::|...|.|||.|.:.|.:::..:|.|:|:|.:|.|||.     :::||..:
Zfish   131 IM--TKAIVRYNGLITWTPPASYKSACTMDVTFFPFDRQNCSMKFGSWTYDGNMVELVLVNH--- 190

  Fly   205 RGESLDHDDLVQSPEWEIVDSRAHFVSQ---DY-YGYMEYTLTAQRRSSMYTAVIYTPASCIVIL 265
               .:|..|...:.||||:.:..|..|:   .| |.|:.|:...:|....||..:..|...:..|
Zfish   191 ---QVDRSDFFDNGEWEILSATGHKGSRRDGHYSYPYITYSFILKRLPLFYTLFLIIPCLGLSFL 252

  Fly   266 ALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVE 330
            .:..|:||.. .|||:.::..:::.:..||:...:::|..|...||:..:....::::::|.||.
Zfish   253 TVLVFYLPSD-EGEKVSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVT 316

  Fly   331 VLVLYLATGKHKR------------------RLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKT 377
            |.|:.:    |.|                  |||:.|  .:.|:...:....:     |.|:...
Zfish   317 VFVINV----HHRSSATYHPMSPWVRTLFLQRLPDLL--CMRGNTDRYHYPQM-----EPQSPDL 370

  Fly   378 KEMDEH--PYEEADEQ------ESSPLGINHTEVPGAKANQF------DWALLATAVDRISFVSF 428
            |...:.  |..|.|.|      |.:...:.:.. ...|...|      ||..:|..:|||    |
Zfish   371 KPRSKKGPPGPEGDGQALINMLEQATNSVRYIS-RHIKKEHFIREVVQDWKFVAQVLDRI----F 430

  Fly   429 SLAFLILAI 437
            ..|||.:::
Zfish   431 LWAFLTVSV 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	116/447 (26%)
		Neur_chan_LBD	52..247	CDD:280998	65/212 (31%)
		Neur_chan_memb	255..434	CDD:280999	45/210 (21%)
chrnb3b	NP_775394.1	LIC	5..449	CDD:273305	118/460 (26%)
		Neur_chan_LBD	31..235	CDD:280998	65/211 (31%)
		Neur_chan_memb	242..446	CDD:280999	46/215 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810