Protein Alignment nAChRbeta3 and chrna1

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_571520.1
• Gene: chrna1 / 30725
• ZFINID: ZDB-GENE-980526-137
• Length: 456
• Species: Danio rerio
• Alignment Length: 441
• Identity: 111/441 - (25%)
• Similarity: 195/441 - (44%)
• Gaps: 85/441 - (19%)

  Fly    53 RLHAGLFTNYDSDVQPV--FQGTPTNVSLEM-VVTYIDIDELNGKLTTHCWLNLRWRDEERVWQP 114
            ||...|||.|:..|:||  |: .|..|::.: ::..|.:||:|..:|::..|..:|:|....|.|
Zfish    26 RLVKTLFTGYNKVVRPVSHFK-DPVVVTVGLQLIQLISVDEVNQIVTSNVRLKQQWKDVHLQWNP 89

  Fly   115 SQYDNITQITLKSSEVWTPQITLFNGDEG--GLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLN 177
            ..|..|.:|.:.|:::|.|.:.|:|..:|  .::.||:|.|.|.|...|.|||::.:|||:.:|:
Zfish    90 DDYGGIRKIRIPSTDLWKPDLVLYNNADGDFAIVHETKVLLEHTGMITWTPPAIFKSYCEIVVLH 154

  Fly   178 WPHDKQSCKLKIGSW----GLKVVLPENGTARGESLDHDDL---VQSPEWEIVDSRA--HFVSQD 233
            :|.|.|:|.:|:|:|    .|.::.|::        |..||   ::|.||.:.|.|:  |:|
Zfish   155 FPFDLQNCSMKLGTWTYDGNLVIINPDS--------DRPDLSNFMESGEWVMKDYRSWKHWV--- 208

  Fly   234 YYG------YME--YTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIV 290
            ||.      |::  |.....|....:...:..|......|....|:||.. .|||:.::..:::.
Zfish   209 YYACCPDTPYLDITYHFLLLRLPLYFIVNVIIPCMLFSFLTGLVFYLPTD-SGEKMTLSISVLLS 272

  Fly   291 IAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYLATGKHKRR-----LPEALR 350
            :..||:...:|:|..|:..||:..:...:::::..|.|:.|:|:    ..|.|.     :|..:|
Zfish   273 LTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVIASIIITVIVI----NTHHRSPSTHIMPAWVR 333

  Fly   351 KLLHGHLGTWLLLSVFSTTGESQAEK---------------------------TKEMDEHPYEE- 387
            |:....:...:..|......:.:.||                           ||..|.....|
Zfish   334 KIFIDTIPNMMFFSTMKRPSQERQEKRLFPADFDISDISGKPMPASVTYHSPITKNPDVRSAIEG 398

  Fly   388 ----ADEQESSPLGINHTEVPGAKANQFDWALLATAVDRISFVSFSLAFLI 434
                ||..:|.....|..|         :|..:|..:|.|....|....:|
Zfish   399 VKYIADTMKSDEESNNAAE---------EWKFVAMVLDHILLCVFMAVCII 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	111/441 (25%)
		Neur_chan_LBD	52..247	CDD:280998	68/215 (32%)
		Neur_chan_memb	255..434	CDD:280999	41/215 (19%)
chrna1	NP_571520.1	LIC	21..447	CDD:273305	111/441 (25%)
		Neur_chan_LBD	24..231	CDD:280998	69/216 (32%)
		Neur_chan_memb	238..446	CDD:280999	42/217 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48230
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920