DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta3 and HTR3E

DIOPT Version :9

Sequence 1:NP_525098.1 Gene:nAChRbeta3 / 33228 FlyBaseID:FBgn0031261 Length:441 Species:Drosophila melanogaster
Sequence 2:NP_001243543.1 Gene:HTR3E / 285242 HGNCID:24005 Length:482 Species:Homo sapiens


Alignment Length:471 Identity:96/471 - (20%)
Similarity:176/471 - (37%) Gaps:138/471 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 TPKIKAPVSGP-----GLPLLLQMLMGMLLMGLTSVPGATAT----------ADPKNANVKALDR 53
            ||:   |..||     ....||.:...|...|    .|.|.|          |||...|      
Human    10 TPR---PALGPLSYREHRVALLHLTHSMSTTG----RGVTFTINCSGFGQHGADPTALN------ 61

  Fly    54 LHAGLFTNYDSDVQPVFQ-GTPTNVSLEMVVTYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQY 117
               .:|..  ...:||.. ..||.|::...::.|              |::.|.:....|.|.:.
Human    62 ---SVFNR--KPFRPVTNISVPTQVNISFAMSAI--------------LDVVWDNPFISWNPEEC 107

  Fly   118 DNITQITLKSSEVWTPQITLFN--------------GDE-------GGLMAETQVT------LSH 155
            :.||::::.:..:|.|.|.:..              |..       |.||...:..      :|:
Human   108 EGITKMSMAAKNLWLPDIFIIELCVSRAGQREVPSPGSHRDHSLPLGPLMDVDKTPKGLTAYVSN 172

  Fly   156 DGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGESLDHDDLVQSPEW 220
            :|..|:..|....:.|.|::..:|.|:|:|.|...|:...|          :|:..|  ::...|
Human   173 EGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTV----------DSMLLD--MEKEVW 225

  Fly   221 EIVDSRAHFVSQ--------------------DYYGYMEYTLTAQRRSSMYTAVIYTPASCIVIL 265
            ||.|:..:.:..                    :.|..:.:.:..:||.|:|...:..|:..:|.:
Human   226 EITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAI 290

  Fly   266 ALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVE 330
            ...:|:||. ..|.::.....|::....||:..:.|||  ::.|||:.::::. .|.|.|.:::|
Human   291 DALSFYLPV-KSGNRVPFKITLLLGYNVFLLMMSDLLP--TSGTPLIGVYFAL-CLSLMVGSLLE 351

  Fly   331 VL----VLYLATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEMDEHPYEEADEQ 391
            .:    :|::||.:     |..|.:.||.      ||...::.|..            ...|.::
Human   352 TIFITHLLHVATTQ-----PPPLPRWLHS------LLLHCNSPGRC------------CPTAPQK 393

  Fly   392 ESSPLGINHTEVPGAK 407
            |:...|:..|.:||.|
Human   394 ENKGPGLTPTHLPGVK 409

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta3NP_525098.1 LIC 39..437 CDD:273305 85/431 (20%)
Neur_chan_LBD 52..247 CDD:280998 40/242 (17%)
Neur_chan_memb 255..434 CDD:280999 36/157 (23%)
HTR3ENP_001243543.1 Neur_chan_LBD 70..273 CDD:280998 40/228 (18%)
Neur_chan_memb 280..>379 CDD:280999 28/113 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5722
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.760

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