DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta3 and Chrng

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_062018.1	Gene:	Chrng / 25753	RGDID:	2354	Length:	519	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	124/505 - (24%)
Similarity:	202/505 - (40%)	Gaps:	107/505 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GPGLPLLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTP-TN 76
            ||.|.|||          |.:..||.:    :|..    :||.|.|..|||..::|..:.:. .|
  Rat     6 GPQLLLLL----------LATCLGAQS----RNQE----ERLLADLMRNYDPHLRPAERDSDVVN 52

  Fly    77 VSLEMVVT-YIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNG 140
            |||::.:| .|.::|....|||:.|:.::|.|....|.|..|:.:..:.:.|:.||.|.|.|.|.
  Rat    53 VSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPKDYEGLWILRVPSTMVWQPDIVLGNN 117

  Fly   141 DEG--GLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKV------V 197
            .:|  .:.....|.:|.||...|:|||::.:.|.:::..:|.|.|:|.|...|.....      :
  Rat   118 VDGVFEVALYCNVLVSPDGCIYWLPPAIFRSSCSISVTYFPFDWQNCSLVFQSQTYSTSEINLQL 182

  Fly   198 LPENGTA-RGESLDHDDLVQSPEWEIVDSRAHFV-----SQDYYGYME--YTLTAQRRSSMYTAV 254
            ..|:|.| ....:|.:...::.||.|....|..:     ..:..|:.:  :.|..||:...|...
  Rat   183 SQEDGQAIEWIFIDPEAFTENGEWAIRHRPAKMLLDPVTPAEEAGHQKVVFYLLIQRKPLFYVIN 247

  Fly   255 IYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTS 319
            |..|...|..:|:..::||...||:|..:...:::....||...|:.:|..|...||:    |..
  Rat   248 IIVPCVLISSVAILIYFLPAKAGGQKCTVATNVLLAQTVFLFLVAKKVPETSQAVPLI----SKY 308

  Fly   320 LLYLSVSTIV----EVLVL----------YLATGKHK---RRLPEALR----------------K 351
            |.:|.|.||:    .|:||          .:|.|..|   |.||:.||                :
  Rat   309 LTFLMVVTILIVVNSVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVHPRAPAAVQDARLR 373

  Fly   352 LLHGHLGTW----------------LLLSVFSTTGESQA-----EKTKEMDEHPYEEADEQESSP 395
            |.:|....|                ||.......|..||     |...||.:........:::||
  Rat   374 LQNGSSSGWPIMTREEGDLCLPRSELLFRQRQRNGLVQAVLEKLENGPEMRQSQEFCGSLKQASP 438

  Fly   396 ------------LGINHTEVPGAKANQFDWALLATAVDRISFVSFSLAFL 433
                        ....|.:......|: :|.|:...:||:.|::....|:
  Rat   439 AIQACVDACNLMARARHQQSHFDSGNE-EWLLVGRVLDRVCFLAMLSLFI 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	115/479 (24%)
		Neur_chan_LBD	52..247	CDD:280998	58/212 (27%)
		Neur_chan_memb	255..434	CDD:280999	54/245 (22%)
Chrng	NP_062018.1	LIC	23..497	CDD:273305	115/474 (24%)
		Neur_chan_LBD	26..241	CDD:280998	59/218 (27%)
		Neur_chan_memb	248..494	CDD:280999	54/245 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910