DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta3 and Chrna7

DIOPT Version :9

Sequence 1:NP_525098.1 Gene:nAChRbeta3 / 33228 FlyBaseID:FBgn0031261 Length:441 Species:Drosophila melanogaster
Sequence 2:NP_036964.3 Gene:Chrna7 / 25302 RGDID:2348 Length:502 Species:Rattus norvegicus


Alignment Length:464 Identity:108/464 - (23%)
Similarity:195/464 - (42%) Gaps:86/464 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 RLHAGLFTNYDSDVQPVFQGT-PTNVSLEM-VVTYIDIDELNGKLTTHCWLNLRWRDEERVWQPS 115
            ||:..|..||:...:||...: |..|...: ::..:|:||.|..|||:.||.:.|.|....|..|
  Rat    28 RLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMS 92

  Fly   116 QYDNITQITLKSSEVWTPQITLFNGDEGGLMA--ETQVTLSHDGHFRWMPPAVYTAYCELNMLNW 178
            :|..:..:.....::|.|.|.|:|..:....|  .|.|.::..||.:::||.::.:.|.:::..:
  Rat    93 EYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWF 157

  Fly   179 PHDKQSCKLKIGSW---GLKVVLPENGTARGESLDHDDLVQSPEWEIV------DSRAHFVSQDY 234
            |.|.|.||||.|||   |..:.|      :.:..|....:.:.||:::      :.:.:...::.
  Rat   158 PFDVQQCKLKFGSWSYGGWSLDL------QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEP 216

  Fly   235 YGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFA 299
            |..:.||:|.:||:..|...:..|...|..|||..|.||.. .||||.:...:::.:..|::..|
  Rat   217 YPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPAD-SGEKISLGITVLLSLTVFMLLVA 280

  Fly   300 QLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVL-YLATGKHKRRLPEALRKLLHGHLGTWL-- 361
            :::|..|::.||:..:::::::.:.:|.:|.|:|| |........::|:..|.:|......:|  
  Rat   281 EIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRM 345

  Fly   362 --------------------LLSVFSTTGESQAEKTKEM-------------------------- 380
                                |.||..:.|.........:                          
  Rat   346 KRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRL 410

  Fly   381 ------DEHPYEEADEQESSPLGINHTEVPGAKANQF-----------DWALLATAVDRISFVSF 428
                  |||....|...:..|......|.....||:|           :|...|..|||:..::|
  Rat   411 ACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAF 475

  Fly   429 SLAFLILAI 437
            |:..:|..|
  Rat   476 SVFTIICTI 484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta3NP_525098.1 LIC 39..437 CDD:273305 107/462 (23%)
Neur_chan_LBD 52..247 CDD:280998 55/206 (27%)
Neur_chan_memb 255..434 CDD:280999 48/244 (20%)
Chrna7NP_036964.3 LIC 4..490 CDD:273305 108/464 (23%)
Neur_chan_LBD 26..230 CDD:280998 56/207 (27%)
Neur_chan_memb 237..486 CDD:280999 50/249 (20%)
Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane. /evidence=ECO:0000250|UniProtKB:P49582 260..267 3/6 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000891
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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