DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRbeta3 and Chrna3

DIOPT Version :9

Sequence 1:NP_525098.1 Gene:nAChRbeta3 / 33228 FlyBaseID:FBgn0031261 Length:441 Species:Drosophila melanogaster
Sequence 2:NP_434692.2 Gene:Chrna3 / 25101 RGDID:2345 Length:499 Species:Rattus norvegicus


Alignment Length:520 Identity:117/520 - (22%)
Similarity:211/520 - (40%) Gaps:141/520 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 LPLLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNVSLE 80
            ||..|.|||.:|::    :|.|:|:        :|..||...||.:|:..::||     .|||..
  Rat     6 LPPPLSMLMLVLML----LPAASAS--------EAEHRLFQYLFEDYNEIIRPV-----ANVSHP 53

  Fly    81 MVVTY-------IDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLF 138
            :::.:       :.:||:|..:.|:.||...|.|.:..|:||.|..:..:.:.:.::|.|.|.|:
  Rat    54 VIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLY 118

  Fly   139 NGDEGGLMAE--TQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWG-----LKV 196
            |..:|....:  |:..|.:.|...|:|||::.:.|::::..:|.|.|:|.:|.|||.     :.:
  Rat   119 NNADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDL 183

  Fly   197 VLPENGTARGESLDHDDLVQSPEWEIVDSRA--HFVS----QDYYGYMEYTLTAQRRSSMYTAVI 255
            ||      .|.|::..|..:|.||.|:.:..  |.:.    ::.|..:.|:|..:|....||..:
  Rat   184 VL------IGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINL 242

  Fly   256 YTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSL 320
            ..|...|..|.:..|:||... |||:.:...:::.:..||:...:.:|..|...||:..:...::
  Rat   243 IIPCLLISFLTVLVFYLPSDC-GEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTM 306

  Fly   321 LYLSVSTIVEVLVL---YLATGKHKRRLPEALRKLLHGHLGTWLLLSVF------------STTG 370
            :::::|.::.|.||   |.....|.              :.|| :.:||            .|:|
  Rat   307 IFVTLSIVITVFVLNVHYRTPTTHT--------------MPTW-VKAVFLNLLPRVMFMTRPTSG 356

  Fly   371 ESQAEKTK--------------EMDEHPYEEADEQESSPLGINH---TEVPGAKAN--------- 409
            |....||:              ..|....:|....:....|..|   .::....||         
  Rat   357 EGDTPKTRTFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSES 421

  Fly   410 -------------------------------------QFDWALLATAVDRISFVSFSLAFLILAI 437
                                                 |.||..:|..:|||    |...|:::.|
  Rat   422 VDAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRI----FLWVFILVCI 482

  Fly   438  437
              Rat   483  482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta3NP_525098.1 LIC 39..437 CDD:273305 107/495 (22%)
Neur_chan_LBD 52..247 CDD:280998 57/214 (27%)
Neur_chan_memb 255..434 CDD:280999 45/256 (18%)
Chrna3NP_434692.2 LIC 24..490 CDD:273305 108/498 (22%)
Neur_chan_LBD 29..235 CDD:280998 58/216 (27%)
Neur_chan_memb 242..489 CDD:280999 46/261 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.910

Return to query results.
Submit another query.