Protein Alignment nAChRbeta3 and Chrnb1

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_001382047.1
• Gene: Chrnb1 / 24261
• RGDID: 2349
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 506
• Identity: 114/506 - (22%)
• Similarity: 212/506 - (41%)
• Gaps: 109/506 - (21%)

  Fly    22 MLMGMLL-----MGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQ-----GTPTN 76
            |.:|.||     :|....|||..:        :|..:|...||::|||.|:|..:     |....
  Rat     1 MALGALLLILGILGTPLAPGARGS--------EAEGQLLKKLFSDYDSSVRPAQEVGDRVGVSIG 57

  Fly    77 VSLEMVVTYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGD 141
            ::|..:::.:..:|.:.:::|..:|:|.|.|....|.|:::|.|..:.:.:..||.|.:.|.|.:
  Rat    58 LTLAQLISLVRENEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIESLRVTAESVWLPDVVLLNNN 122

  Fly   142 EGG--LMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW-------GLKVV 197
            :|.  :..:..|.:|.:|..||.||.:|.:.|.:.:..:|.|.|:|.:...|:       .||..
  Rat   123 DGNFDVALDINVVVSFEGSVRWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLKTG 187

  Fly   198 LPENGTARGESLDHD-DLVQSPEWEIV--DSRAHFVSQDYYGYME-------YTLTAQRRSSMYT 252
            ...:|..|.|...|: ..:::.:|||:  .||...:..|..|..|       :.|..:|:...|.
  Rat   188 PDPDGQERQEIYIHEGTFIENGQWEIIHKPSRLIHLPGDRRGGKEGHREEVIFYLIIRRKPLFYL 252

  Fly   253 AVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYS 317
            ..:..|...|.:||:..|:|||. .|||:.::...::.:..||:..|..:|..|...|:::.:..
  Rat   253 VNVIAPCILITLLAIFVFYLPPD-AGEKMGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLM 316

  Fly   318 TSLLYLSVSTIVEVLVLYL-ATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEMD 381
            .:::.::.|.|:.|:||.| ....|..::|..:|::....|..:|        |..:.:..::..
  Rat   317 FTMILVTFSVILSVVVLNLHHRSPHTHQMPFWVRQIFIHKLPPYL--------GLKRPKPERDQL 373

  Fly   382 EHPYEE----------ADE------------------QESSP--------------LGINH---- 400
            ..|:..          .||                  |..||              :|:..
  Rat   374 PEPHHSFSPRSGWGRGTDEYFIRKPPCDFLFPKLNRFQPESPAPDLRRFIDGPPRAVGLPQELRE 438

  Fly   401 ------------TEVPGAKANQFDWALLATAVDRI---SFVSF-SLAFLIL 435
                        .|.....|.:.||..:|..|||:   :|:.| |:..|::
  Rat   439 VISSISYMARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVI 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	106/484 (22%)
		Neur_chan_LBD	52..247	CDD:280998	55/218 (25%)
		Neur_chan_memb	255..434	CDD:280999	47/241 (20%)
Chrnb1	NP_001382047.1	LGIC_ECD_nAChR_B1	27..248	CDD:349825	56/220 (25%)
		Neur_chan_memb	255..490	CDD:397193	48/244 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..384		1/18 (6%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810