Protein Alignment nAChRbeta3 and HTR3D

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_001157118.1
• Gene: HTR3D / 200909
• HGNCID: 24004
• Length: 454
• Species: Homo sapiens
• Alignment Length: 436
• Identity: 87/436 - (19%)
• Similarity: 151/436 - (34%)
• Gaps: 102/436 - (23%)

  Fly    14 PGLPLLLQMLMGMLLMG-----LTSVPG-ATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQG 72
            ||.|.|..:...:|..|     :.:.|| .....||. |.....||...|..|||.       ..
Human     6 PGPPALALLSQSLLTTGNGDTLIINCPGFGQHRVDPA-AFQAVFDRKAIGPVTNYS-------VA 62

  Fly    73 TPTNVSLEMVVTYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITL 137
            |..|:|..:...:.....::   |.:|.....|.::...|.|.:...|.:..:.:..:|...:.:
Human    63 THVNISFTLSAIWNCYSRIH---TFNCHHARPWHNQFVQWNPDECGGIKKSGMATENLWLSDVFI 124

  Fly   138 ---FNGDEGGLMAE------TQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWG 193
               .:....||||.      |..|:|..|   |...|           ||.........:..:|
Human   125 EESVDQTPAGLMASMSIVKATSNTISQCG---WSASA-----------NWTPSISPSMDRARAW- 174

  Fly   194 LKVVLPENGTARGESLDHDDLVQS-PEWEIVDSRAH----FVSQDYYGYMEYTLTAQR--RSSMY 251
                   ...:|...:.|....:: .||.::..:..    .|:.:.|....:.:..:|  |.|.|
Human   175 -------RRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPSPY 232

  Fly   252 TAVIYTPASCIVILALSAFWLPPHMGG---EKIMINGLLIIVIAAFLMYFAQLLPVLSNN----- 308
            ......|:..::.:...:|:||...|.   .|:.:    ::..:.||:....|||..|.:
Human   233 VVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTV----LLGYSVFLLMMNDLLPATSTSSHASL 293

  Fly   309 --------TPLVVIFYSTSLLYLSVSTIVEVL----VLYLATGKHKRRLPEALRKLLHGHLGTWL 361
                    |||....|....|.|.|.:::|.:    :|::||   .:.||          |..||
Human   294 VAPLALMQTPLPAGVYFALCLSLMVGSLLETIFITHLLHVAT---TQPLP----------LPRWL 345

  Fly   362 LLSVFSTTGESQAEKTKEMDEHPYEEADEQESSPLGINHTEVPGAK 407
            ...:...||:.:...|          |.::.:...|:..|.:||.|
Human   346 HSLLLHCTGQGRCCPT----------APQKGNKGPGLTPTHLPGVK 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	79/405 (20%)
		Neur_chan_LBD	52..247	CDD:280998	36/210 (17%)
		Neur_chan_memb	255..434	CDD:280999	37/173 (21%)
HTR3D	NP_001157118.1	Neur_chan_LBD	55..>130	CDD:280998	13/84 (15%)
		LIC	92..452	CDD:273305	65/339 (19%)
		Neur_chan_memb	237..>351	CDD:280999	28/130 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..410		5/19 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900