Protein Alignment nAChRbeta3 and acr-18

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_506868.2
• Gene: acr-18 / 191604
• WormBaseID: WBGene00000057
• Length: 510
• Species: Caenorhabditis elegans
• Alignment Length: 498
• Identity: 102/498 - (20%)
• Similarity: 200/498 - (40%)
• Gaps: 97/498 - (19%)

  Fly    26 MLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNVSLEMVVTY----- 85
            ::|..:.|.....||:.|....::   .|:..||.:|..:::||   ...:.||::.:.:
 Worm     8 LILWQILSSHRVHATSHPARTPMR---NLYEHLFLDYVKEIRPV---RNESESLKVEIKFWLKQI 66

  Fly    86 IDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNG-----DEGGL 145
            :.:||.:..:..:|||.|.|.||...|.|.::.|:::|.:.:.::|.|.:.::|.     :|..:
 Worm    67 LKVDERDQIVNIYCWLELYWIDETLTWDPKKFGNLSRIHVPAHKIWKPDVLVYNNANMNVEENEM 131

  Fly   146 MAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPENGTARGE 207
              ||...:.:.|........:....|.||:..:|.|:|.|.:...||   |.|:.|  :.|.:.:
 Worm   132 --ETNAIVDNTGRVMLFRSMITDISCNLNLQQFPFDQQICFVTFASWSMDGSKLDL--SATPKTD 192

  Fly   208 SLDHDDLVQSPEWEIVDSRAHFVSQDY------YGYMEYTLTAQRRSSMYTAVIYTPASCIVILA 266
            :|:.  .:::.||.:.|.|.....:.|      :..:.|.:..:|..|.|...:..|::.|.::.
 Worm   193 NLEL--YIRNTEWGLTDFRVKIYQKIYDCCPHPFPDVTYFMVLRRSPSYYIFSLVIPSAFITVVT 255

  Fly   267 LSAFWLPPHMGG---EKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTI 328
            :..|:.|....|   ||:.:....::.:|..:|..:..:|..|...||:..:|...:..:.::..
 Worm   256 IVGFFTPHSTTGENTEKVSLGVTALLSMAIIMMMVSDEVPATSEVIPLIGKYYIGLIFLIFMAAF 320

  Fly   329 VEVLVL-YLATGKHKRRLPEALRKLLHGHLG-----TWL--------LL-------SVFSTTGES 372
            ...|.| |...|...:.:...:|......:.     :|.        ||       |.|.|.|.:
 Worm   321 TTTLTLSYQMRGNSGQEVDPRVRDFFFYQIAANPCISWAFSFQLPKKLLRSDHRKQSFFFTNGAA 385

  Fly   373 QAEKTKEMDEHP---------YEEAD----------EQESSPLGINHTE--------VPGAKAN- 409
            ......:...||         .||..          .|||:......|.        :...||:
 Worm   386 HVNGYSKGALHPNTPPAHIVKMEEITGGGSVKSFVMSQESAATSTLLTSSLMKIKVVLDDMKASI 450

  Fly   410 ---------QFDWALLATAVDR---ISFVSFSLAF--LILAIR 438
                     :|:|..:...:||   .|::..::||  ::||.|
 Worm   451 HAERELKRIKFEWQQVTRLIDRCIMFSYILITIAFAMVMLASR 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	98/482 (20%)
		Neur_chan_LBD	52..247	CDD:280998	48/213 (23%)
		Neur_chan_memb	255..434	CDD:280999	43/244 (18%)
acr-18	NP_506868.2	Neur_chan_LBD	33..237	CDD:280998	49/212 (23%)
		Neur_chan_memb	244..486	CDD:280999	42/241 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810