DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta3 and acr-11

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_491906.1	Gene:	acr-11 / 191599	WormBaseID:	WBGene00000050	Length:	461	Species:	Caenorhabditis elegans

Alignment Length:	474	Identity:	116/474 - (24%)
Similarity:	207/474 - (43%)	Gaps:	84/474 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGT-PTNVSLEMV 82
            |:..::.::::......|:.|..           :|...|...|:...:||...: |..|.:::.
Worm     5 LINSILSLVIIHSNLCDGSVAET-----------KLFTDLLKGYNPLERPVQNSSQPLEVKIKLF 58

  Fly    83 VTYI-DIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITL--KSSEVWTPQITLFN--GDE 142
            :..| |:||.|..::.:.||:..|.|.:..|:|.:|..|..|..  .|..:|.|.:.|:|  .::
Worm    59 LQQILDVDEKNQIVSVNAWLSYTWFDHKLQWEPKKYGGIQDIRFPGSSDHIWKPDVLLYNSAAED 123

  Fly   143 GGLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW-------GLKVVLPE 200
            .....::.:...|.|...|:||.|....|:|::..:|.|.|.|::|.|||       .|::....
Worm   124 FDSTFKSNLLTYHTGTVVWIPPGVLKFVCQLDVTWFPFDDQVCEMKFGSWTFHGYAIDLQIDDDT 188

  Fly   201 NGTARGESLDHDDLVQSPEWEIVDSRAHFVSQDY------YGYMEYTLTAQRRSSMYTAVIYTPA 259
            |||   :|:|....:.:.||:::.:.|..|...|      |..:.|.|..:||:..|...:..|:
Worm   189 NGT---QSMDLSTYLVNGEWQVISTNAKRVVSYYKCCPEPYPTVNYYLHIRRRTLYYGFNLIIPS 250

  Fly   260 SCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLS 324
            ..|.::|:..|..||. .||||.:...:::.|..||...:::.|..|...||:.:|:|..:|.:|
Worm   251 LLISLMAILGFMFPPD-AGEKITLEVTILLAIVFFLSMVSEMTPPTSEAVPLIGVFFSCCMLVVS 314

  Fly   325 VSTIVEVLVLYL---ATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTG-----ESQAEKTKEMD 381
            .|.:..::||.|   :...|:  :...:|::|...| .|||.  .|..|     .:..:.|.:|.
Worm   315 ASVVFTIVVLNLHFRSADSHE--MNPLVRRVLLEFL-PWLLF--MSRPGYKFVKANVIDSTDKMP 374

  Fly   382 EHPYEEADEQESSPLGIN------------------HTEVPGAKA----------NQFDWALLAT 418
            :.|        .:||..|                  |||:....|          .|.||...|.
Worm   375 KKP--------KNPLDCNLPSNHAGYEAQILLLHSVHTELRRVVAFYNKEEHDERIQTDWRFAAM 431

  Fly   419 AVDRISFVSFSLAFLILAI 437
            .|||...:.|:: |::::|
Worm   432 VVDRACLLLFTV-FIVISI 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	113/452 (25%)
		Neur_chan_LBD	52..247	CDD:280998	56/213 (26%)
		Neur_chan_memb	255..434	CDD:280999	53/214 (25%)
acr-11	NP_491906.1	LIC	25..456	CDD:273305	114/454 (25%)
		Neur_chan_LBD	26..239	CDD:280998	57/226 (25%)
		Neur_chan_memb	246..447	CDD:280999	53/215 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910