Protein Alignment nAChRbeta3 and acr-9

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_510285.2
• Gene: acr-9 / 191597
• WormBaseID: WBGene00000048
• Length: 534
• Species: Caenorhabditis elegans
• Alignment Length: 507
• Identity: 129/507 - (25%)
• Similarity: 203/507 - (40%)
• Gaps: 129/507 - (25%)

  Fly    53 RLHAGLFTNYDSDVQPVFQGT-PTNVSLEMVVTYI-DIDELNGKLTTHCWLNLRWRDEERVWQPS 115
            ||.|.|..|||...:||...: |..||:::.:..| |:||.|..:|...|:..:|.|.:..|.||
 Worm    30 RLLADLRHNYDPYERPVANASEPLVVSVKIYLQQILDVDEKNQVITLVAWIEYQWTDYKLKWDPS 94

  Fly   116 QYDNITQITL--KSSEVWTPQITLFNGDEGGLMAETQV--TLSHDGHFRWMPPAVYTAYCELNML 176
            :|..|..|.:  .::.:|.|.:.|:|..:....:...|  .:|:.|....:||.:....|::::.
 Worm    95 EYGGIKDIRIPGNANAIWKPDVLLYNSADENFDSTYPVNYVVSYTGDVLQVPPGILKLSCKIDIT 159

  Fly   177 NWPHDKQSCKLKIGSW-------GLKVVLPENGTARGESLDHDDLVQSPEWEIVDSRAH-----F 229
            .:|.|.|.|.||.|||       .|::..||......|.:|....||:.||.::...|.     |
 Worm   160 YFPFDDQICHLKFGSWTYSGNFIDLRINGPEGKNISDEGIDVQYYVQNGEWNLLAVPARHETNIF 224

  Fly   230 VSQDYYGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAF 294
            ..|.|.....| |..|||:..|...:..|:..|.::.:..|.|||. .||||.:...:::.:..|
 Worm   225 DEQPYPSLFFY-LIIQRRTLYYGLNLIIPSFLISLMTVLGFTLPPD-AGEKITLEITILLSVCFF 287

  Fly   295 LMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYLATGKHKRRLPEA------LRKLL 353
            |...|.:.|..|...||:..|:|..:|.:|.|.:..||||.|    |.|: ||.      ||:||
 Worm   288 LSMVADMTPPTSEAVPLIGAFFSCCMLVVSASVVFTVLVLNL----HNRK-PETHEMSPFLRELL 347

  Fly   354 HGHLGTWLLL------SVFSTTGESQAEKTKEMDE-----------------HPYEEADEQESSP 395
            ...| .||||      ::|:.| ..:|||.:|..:                 ||.|.....::..
 Worm   348 LIWL-PWLLLMRRPGKTIFNCT-HLKAEKAEEKAKQGSIKNGVGPGKPTDSVHPSEGLSLMKNIK 410

  Fly   396 LGINHT--------------------------------------EVPGAKANQF----------- 411
            ||...|                                      :|...:.|::
 Worm   411 LGRQQTIDFEYEFHVQHNHLMPVAPSEMTPRVTYSKVMAESYVEDVVMTELNKYMQKACLELKNI 475

  Fly   412 ----------------------DWALLATAVDRISFVSFSLAFLILAIRCSV 441
                                  ||...|..|||...::||: |:::: .|.:
 Worm   476 SSQTRAMRKKMEEDERDEQAANDWKFAAMVVDRCCLITFSV-FIVVS-TCGI 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	128/501 (26%)
		Neur_chan_LBD	52..247	CDD:280998	62/211 (29%)
		Neur_chan_memb	255..434	CDD:280999	63/278 (23%)
acr-9	NP_510285.2	LIC	28..525	CDD:273305	129/505 (26%)
		Neur_chan_LBD	28..242	CDD:280998	63/212 (30%)
		Neur_chan_memb	249..525	CDD:280999	64/285 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5722
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860