Protein Alignment nAChRbeta3 and acr-5

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_001367477.1
• Gene: acr-5 / 191596
• WormBaseID: WBGene00000044
• Length: 598
• Species: Caenorhabditis elegans
• Alignment Length: 527
• Identity: 113/527 - (21%)
• Similarity: 198/527 - (37%)
• Gaps: 131/527 - (24%)

  Fly    28 LMGLTSVPGATATADPKNANVKALDRLHAGLFTN--------------YDSDVQPVFQGT-PTNV 77
            |...|:...||...:......:.|::|:.|.|.|              |:..|.|....| ||.|
 Worm    69 LENTTAAYNATFMQELIEERQRYLEKLNEGQFINDQRRLVEELLDPNYYEKTVHPKRDYTRPTRV 133

  Fly    78 SLEM-VVTYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGD 141
            :|.| :...:|:||....:..:.|:...|.||...|.|..|..|.:..:...::|.|...|:|.:
 Worm   134 NLSMSLYQILDVDEHMQSIEVNVWMVQHWYDEFLDWNPVDYGMINRTIVPYHQIWIPDTYLYNSE 198

  Fly   142 E------GGLMAETQVTLSH-----DG-HFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGL 194
            |      ..|| ..|:...|     || ..:.|.||:|...|.:::..:|:|:|:|...|.||
 Worm   199 ELEQKKTESLM-NAQLETGHWNQKKDGAKVQLMFPAIYKLSCRMDVRWFPYDRQNCTFIISSW-- 260

  Fly   195 KVVLPENGTARGESLDH---------DDLVQSPEWEIVDSRAHFVSQDYY-----GYMEYTLTAQ 245
                    |...:::|:         .::.::.|||::......|.:.:.     ..|.|.....
 Worm   261 --------THDKQTIDYWPLSSTVNLGNMARNDEWEVISFEFVRVEETFKCCTAPWVMLYAHLVI 317

  Fly   246 RRSSMYTAV-IYTPASCIVILALSAFWLPPHMGGEK-----IMINGLLIIVIAAFLMYFAQLLPV 304
            ||..:|..: :..|.|.|.|:|::.|:.|.....|:     :.||.||  .::..::.....:|.
 Worm   318 RRKPLYYMINLVVPTSIITIVAVTGFFTPTSSSSERDEKLYLGINTLL--TMSVMMLMVCNQMPS 380

  Fly   305 LSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYLATGKH-KRRLPEALRKLLHG------------- 355
            .|...||:..:|...::.:.|.|.:...||.:...|| .:.:.:.:|||::.
 Worm   381 TSTYVPLMSWYYIGIIMVIVVGTFLATGVLAIHGQKHYNKPISDRIRKLIYNPVVEFFILSPPTS 445

  Fly   356 ------------------HLGTWL----------------------------LLSVFSTTGESQA 374
                              ||...|                            |.|.:|.|.. .|
 Worm   446 LIDLWTEFGVISEQRHSTHLDPLLLQHMDPISHTTRADPQHFFGSISSQMCDLQSTYSYTAR-LA 509

  Fly   375 EKTKEMDEHPYEEADEQESSPLGINHTEVPGAKANQ------FDWALLATAVDRI---SFVSFSL 430
            ..|::..:|...:|..:....:.::.::..|.|..:      .:|..||..:|||   .|..|:.
 Worm   510 TITRQYTQHAKMKALRKNQYRMSMDTSQARGVKKQKMQRRCSLEWEFLANVLDRILLTIFCGFTF 574

  Fly   431 AFLILAI 437
            |..|:.|
 Worm   575 AVFIILI 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	108/514 (21%)
		Neur_chan_LBD	52..247	CDD:280998	55/236 (23%)
		Neur_chan_memb	255..434	CDD:280999	48/252 (19%)
acr-5	NP_001367477.1	LIC	104..581	CDD:273305	103/490 (21%)
		Neur_chan_LBD	104..321	CDD:397192	53/227 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000