Protein Alignment nAChRbeta3 and acr-6

DIOPT Version :10

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_491354.2
• Gene: acr-6 / 191479
• WormBaseID: WBGene00000045
• Length: 551
• Species: Caenorhabditis elegans
• Alignment Length: 369
• Identity: 100/369 - (27%)
• Similarity: 165/369 - (44%)
• Gaps: 53/369 - (14%)

  Fly    50 ALDRLHAGLFTNYDSDVQP--VFQGTPT---NVSLEMVVTYIDIDE---LNGKLTTHCWLNLRWR 106
            |...|...|...|:....|  .|..|.|   .:.|:.:|...:.|:   |.|.|..|      |.
 Worm    19 AYKSLFETLLARYNKIAFPSGEFNNTLTIEFKLRLDQIVDVHEKDQVITLKGTLIHH------WL 77

  Fly   107 DEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGG--LMAETQVTLSHDGHFRWMPPAVYTA 169
            |....|.|.::.|||.:......:|.|.|.|:|...|.  :...|||.:|.:|...|.||.||.|
 Worm    78 DYRLSWNPDEFGNITLMHFPGEMLWLPDIILYNNAHGSPWVSETTQVHVSFEGRVTWQPPVVYDA 142

  Fly   170 YCELNMLNWPHDKQSCKLKIGSW---GLKVVL--------PENGTARGES-------LDHDDLVQ 216
            :|.:::..:|:|.|.|:||.|||   |.::.|        .|:..|.|::       :|..:..:
 Worm   143 FCNIDIEWYPYDLQICELKFGSWTYGGSQLNLIHLTTDQANESTDATGDNVWKVERGVDLSNYQE 207

  Fly   217 SPEWEI--VDSRAH---FVSQDYYGY-MEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLP-- 273
            |.||::  |:...|   :...||... :.|.|..:|:...||..:..|..|:..:.|..|:||
 Worm   208 SVEWDLLSVEGIRHKKWYPCCDYPSIDITYYLHIRRKKLFYTVNMIIPCVCLASMTLWVFYLPCE 272

  Fly   274 PHMGGEKIMINGLLIIVIAAFLMYFAQL---LPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLY 335
            .|   :||.   |.|.|:.|..:||..|   :|..|..|||::.:.|.:::.:::|....|.:..
 Worm   273 SH---QKIQ---LCISVLVALTLYFLMLIDIIPPTSIVTPLILKYLSFTMIMVALSVTCTVFIQN 331

  Fly   336 LATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKE 379
            :....:.:.:|..::......||..||:|  ..|.::|..:|.:
 Worm   332 IHYRAYYQPMPRFVKHWFIEKLGKKLLIS--RKTEQAQYHRTAQ 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:455710	100/369 (27%)
acr-6	NP_491354.2	LGIC_ECD	21..247	CDD:475126	64/231 (28%)
		LGIC_TM_nAChR	246..>335	CDD:349866	26/94 (28%)
		TM1 helix	246..270	CDD:349866	6/23 (26%)
		Neur_chan_memb	252..524	CDD:460753	33/130 (25%)
		TM2 helix	278..299	CDD:349866	7/23 (30%)
		TM3 helix	310..332	CDD:349866	3/21 (14%)