DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta3 and lgc-19

DIOPT Version :9

Sequence 1:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_502905.2	Gene:	lgc-19 / 190895	WormBaseID:	WBGene00013655	Length:	400	Species:	Caenorhabditis elegans

Alignment Length:	345	Identity:	74/345 - (21%)
Similarity:	151/345 - (43%)	Gaps:	60/345 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LFTNYDSDVQPVFQGTPTNVSLEMVVTY-------------------IDIDELNGKLTTHCWLNL 103
            :|.:||..|.||:    |.|.:::.:.|                   :::.|...|::....:..
Worm    41 IFRDYDPTVSPVY----TWVDVDLPIGYDNEAPKRYNYTIFLYYLKLVEVQEPQEKISVVMEIME 101

  Fly   104 RWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGGLMAETQ---VTLSHDGHFRWMPPA 165
            .|.|....|..|.:.|.|.|.:|..:||:|.|::|..::.....:..   :.:.:.| |.|...:
Worm   102 YWYDARLSWNASAWQNTTMIYMKQDKVWSPTISVFGVNDIVDFRDNDNRLICIENTG-FIWDYVS 165

  Fly   166 V-YTAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGESLD--HDDLVQ--------SPE 219
            | .:|.||:::..:|.|.|.|:::.       .||.....:.:.|:  :::::.        :.|
Worm   166 VRVSANCEMDVSRFPFDTQICQIRF-------CLPIFYRVQVDILNEIYEEIMDERIFKTMGNSE 223

  Fly   220 WEIVD--SRAH-FVSQDYYGYME---YTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGG 278
            |::::  :|.. .|..|..|.|:   :.:|.:|....|..:|..|:..|..:::...:|   .|.
Worm   224 WKLLNLTNRVEALVYNDNMGTMDLAIFEITIRRNPLYYIYMIVFPSFIINFVSIVGVFL---NGA 285

  Fly   279 EKI-MIN-GLLIIVIAAFLM-YFAQLLPVLSNNTPLVVIFYSTSL--LYLSVSTIVEVLVLYLAT 338
            :|: .:| ||..|:...|:: ..|..:| .:.|.||:.|:...:|  :.::::.:..:..|....
Worm   286 DKMSRLNVGLTNIMTMTFILGVMADKIP-RTGNIPLLGIYIIINLVIMLIAIAIVTAITELRKWA 349

  Fly   339 GKHKRRLPEALRKLLHGHLG 358
            ....|:...|||..|...||
Worm   350 SPKLRKKKTALRAQLESFLG 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	74/345 (21%)
		Neur_chan_LBD	52..247	CDD:280998	46/227 (20%)
		Neur_chan_memb	255..434	CDD:280999	26/109 (24%)
lgc-19	NP_502905.2	LGIC_ECD_cation	75..257	CDD:349790	37/189 (20%)
		LGIC_TM_cation	259..>346	CDD:349853	19/90 (21%)
		TM1 helix	263..284	CDD:349853	4/23 (17%)
		TM2 helix	292..313	CDD:349853	6/20 (30%)
		TM3 helix	323..346	CDD:349853	2/22 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48230
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820