Protein Alignment nAChRbeta3 and acr-24

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_001255865.1
• Gene: acr-24 / 190686
• WormBaseID: WBGene00013534
• Length: 578
• Species: Caenorhabditis elegans
• Alignment Length: 412
• Identity: 96/412 - (23%)
• Similarity: 174/412 - (42%)
• Gaps: 65/412 - (15%)

  Fly    62 YDSDVQPVF-QGTPTNVSLEM-VVTYIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQIT 124
            |||.|:||. ...||.||..| :...:.|:|....:..:.|...:|.|:...|.|..|..|....
 Worm    45 YDSRVRPVMNHSKPTTVSFSMSLYQILSINEKQQNVDLNVWAIQKWNDDFLGWNPYLYGMINTTI 109

  Fly   125 LKSSEVWTPQITLFNG-----DEGGLMAETQVTLSH-----DGHFRWMPPAVYTAYCELNMLNWP 179
            |....:|.|...|:|.     :|........||.::     ....::|.||:|...|.|::..:|
 Worm   110 LPFDAIWLPDTYLYNSVVMNREETERYINVVVTTNYWKGETGAEVKFMYPALYRTSCLLDIRFFP 174

  Fly   180 HDKQSCKLKIGSW-GLKVVL---PENGTARGESLDHDDLVQSPEWEIVDSRAHFVSQDY------ 234
            :|:|:|||.|.|| ..|..:   ||:     ||::.|:.:.:.||.:|......|.:.:
 Worm   175 YDQQACKLTISSWTSSKSDINYEPEH-----ESVNMDNFLPNEEWVVVSFNIKRVEEKFVCCPEP 234

  Fly   235 YGYMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEK-----IMINGLLIIVIAAF 294
            :..:|..|..:|:...|...:..|.|.|.::|::.|:.......|:     :.|:.||.:.|  .
 Worm   235 WVLLEAVLVVRRKPLYYIVNLVIPTSVITLVAVTGFFTAASTSSERREKLSLGIDSLLAMSI--L 297

  Fly   295 LMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYLATGK-HKRRLPEALRKLLHGHLG 358
            :|..::.:|..|:..||..|||.:.:..:.:.|:....:|.:...| :.:.:...:..:..|.:.
 Worm   298 MMMVSEQMPTSSDFVPLFGIFYLSIIFIIFIGTLFTAFILNVHLQKMYAKPVSPIVSYIFFGRIA 362

  Fly   359 TWL-------LLSVFSTTGESQAEKTKEMDEHPYEEADEQESSPLGINHTEVPGA---------- 406
            .||       ||.:::.||.:            :.:..::.|..:..||..:|..
 Worm   363 QWLRMRPPTMLLELWNETGVT------------FGKEGQKNSKTIPKNHKMIPKVTSSSSGLHLL 415

  Fly   407 KANQFDW-ALLATAVDRISFVS 427
            |:|.... |.||..:...|::|
 Worm   416 KSNSGSGRAPLAAPISARSYIS 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	96/412 (23%)
		Neur_chan_LBD	52..247	CDD:280998	55/206 (27%)
		Neur_chan_memb	255..434	CDD:280999	39/197 (20%)
acr-24	NP_001255865.1	Neur_chan_LBD	34..248	CDD:280998	56/207 (27%)
		Neur_chan_memb	255..>411	CDD:280999	32/169 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010