Protein Alignment nAChRbeta3 and lgc-1

DIOPT Version :9

• Sequence 1: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_504154.5
• Gene: lgc-1 / 188099
• WormBaseID: WBGene00020236
• Length: 371
• Species: Caenorhabditis elegans
• Alignment Length: 349
• Identity: 75/349 - (21%)
• Similarity: 134/349 - (38%)
• Gaps: 62/349 - (17%)

  Fly    42 DPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNVSLEM-VVTYIDIDELNGKLTTHCWLNLRW 105
            ||   .:.|:..||...:.|..:.:.|..    |.:.|.| ::..:|:.|:..|:|........|
 Worm    28 DP---TLSAIYTLHKSQWINQTATIHPPI----TELKLTMAMLKLVDVVEVEEKVTFLFDYLAEW 85

  Fly   106 RDEERVWQPSQYDNITQITLKSSEVWTPQITL--------FNGDEGGLMAETQVTLSHDGHFRWM 162
            .|:...|.|.:|..|:.|.:....:|.|::|:        |..|:    |.....::::|...:.
 Worm    86 TDQRLKWNPLEYGGISHIYVPQRMIWLPEVTIADAHEVKFFESDD----APRTAWINYNGTTGFY 146

  Fly   163 PPAVYTAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGESLDHDDLVQSP--------- 218
            ...|.:..|:|::..:|.|:..|       |:.|:.  :.....|.:...|:...|
 Worm   147 TSTVSSVICQLDVYKFPLDRHEC-------GVSVLF--HTYFADEYVIKSDMEPLPKPLSQLGNG 202

  Fly   219 EWEIVDSRAHFVSQDYYGYME------------YTLTAQRRSSMYTAVIYTPASCIVILALSAFW 271
            ||::.          |.|..|            :....:|....|..::..||..|..|::.|..
 Worm   203 EWKVT----------YIGVAEEIGNGNFSAVQRFVARIERNPGFYVTLVMVPAFFINFLSIIALC 257

  Fly   272 LPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYL 336
            |.....||||.:....|:.:...|:..||.|| .:...||:.|:....|: :.:::|..||.|.|
 Worm   258 LNIENVGEKITVGLTNIMAMTFILVILAQDLP-KTKRIPLLAIYVIVGLV-IVMASIGVVLTLPL 320

  Fly   337 ATGKHKRRLPEALRKLLHGHLGTW 360
            .....|:|......|.:......|
 Worm   321 IRNHLKKRQKGKEEKPVETRFSKW 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	75/349 (21%)
		Neur_chan_LBD	52..247	CDD:280998	41/224 (18%)
		Neur_chan_memb	255..434	CDD:280999	29/106 (27%)
lgc-1	NP_504154.5	Neur_chan_LBD	84..>335	CDD:332142	59/275 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900